ArticlePest management science2026
Novel histone deacetylase-inhibiting 5-(trifluoromethyl)-1,2,4-oxadiazole derivatives with exceptional efficacy against Phakopsora pachyrhizi.
Chunlan Li, Yuandong Liu, Yuxin Huang, Fanqi Meng, Jing Zhang, Lixin Zhang
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In one paragraphArticle in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Chunlan Li *National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.ORCID https://orcid.org/0009-0008-4523-8051 Yuandong Liu *National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Yuxin Huang *National-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Fanqi MengNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.ORCID https://orcid.org/0009-0007-7872-8252 Jing ZhangNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Lixin ZhangNational-Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology, Liaoning Province Key Laboratory of Green Functional Molecular Design and Development, Shenyang Key Laboratory of Targeted Pesticides, Institute of Functional Molecules, Shenyang University of Chemical Technology, Shenyang, China.
Funding
Education Department of Liaoning Province LJ232410149068;LJ232510149002National Natural Science Foundation of China 22277081
6 · The paper itselfAbstract
backgroundAsian soybean rust caused by Phakopsora pachyrhizi (P. pachyrhizi) poses a serious threat to global soybean production, and resistance to conventional fungicides is increasing. Therefore, new fungicides with novel modes of action are urgently needed. This study aimed to design and optimize potent 5-(trifluoromethyl)-1,2,4-oxadiazole (TFMO) derivatives inspired by fungal histone deacetylase inhibition.
resultsForty-two TFMO derivatives were synthesized through bioisosteric modification and linker optimization. Among them, FM-17888 showed the highest activity against P. pachyrhizi, with an EC
conclusionFM-17888 is a potent and selective TFMO lead compound for soybean rust control. Together with the greenhouse bioassay, docking, and DFT results, these findings support FM-17888 as a promising candidate for further development against rust diseases, while direct target-validation studies are still needed to confirm its precise mode of action. © 2026 Society of Chemical Industry.
Indexed as
BasidiomycotaFungicides, IndustrialHistone Deacetylase InhibitorsOxadiazolesPhakopsora pachyrhiziGlycine maxHistone DeacetylasesMolecular Docking SimulationPlant Diseases1,2,4-oxadiazoleFungicides, IndustrialHistone Deacetylase InhibitorsHistone DeacetylasesOxadiazoles5‐(trifluoromethyl)‐1,2,4‐oxadiazolebioisosterismFM‐17888histone deacetylase inhibitorslinker optimizationPhakopsora pachyrhizisoybean rust
Identifiers
PMID42098912
PMCPMC13453186
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