ArticleJournal of translational medicine2026
Intratumoral microbiota promote pancreatic cancer progression via NaAc-mediated activation of the GPR43/AMPK/HADH pathway.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundIntratumoral microbiota are essential components of tumours and are substantially involved in tumour initiation, progression, and treatment. However, owing to the vast diversity and abundance of microbial species, understanding their molecular mechanisms within tumours, particularly in pancreatic cancer (PC), remains challenging.
methodsMicrobiota composition was analysed in pancreatic cystic neoplasm (PCN) and pancreatic ductal adenocarcinoma (PDAC) tissues using 16S rRNA sequencing. Liquid chromatography-mass spectrometry (LC-MS) was employed in the same samples to quantify tissue metabolites. Subsequently, the association between intratumoral microbiota and metabolites was examined to investigate potential interactions. Western blotting, quantitative real-time polymerase chain reaction, and immunohistochemistry were used to detect the expression of 3-hydroxyacyl-CoA dehydrogenase (HADH), AMP-activated protein kinase (AMPK), and G protein-coupled receptor 43 (GPR43). The biological role of the intratumoral bacterial metabolite sodium acetate (NaAc) was determined through in vitro and in vivo experiments.
resultsCertain bacterial taxa, including Muribaculaceae, Prevotella, Lachnospiraceae NK4A136 group, and Blautia, were significantly enriched in PDAC tissues and were associated with lipid molecules. Specific taxa exhibited positive correlations with lipid molecules in PDAC tissues. Low concentrations of NaAc promoted PC cell proliferation and migration in vitro and enhanced tumour growth in vivo. Mechanistically, NaAc activated the GPR43/AMPK/HADH signalling pathway in PC cells, leading to increased fatty acid oxidation.
conclusionsSpecific intratumoral microbiota contribute to the progression from PCN and PDAC by modulating lipid metabolism. These findings provide a theoretical framework for understanding the microbiota-driven mechanisms in PDAC and highlight their role in tumour growth.
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