Evidence map›Paper›PMID 42098744›Full record

ArticleJournal of neuroinflammation2026

Iba1 deficiency impairs microglial synaptic remodeling and neuronal survival after axonal injury.

Koji Sekiguchi, Hirotaka Shoji, Tomoko Shindo, Jumpei Sasabe, Daiki Tokuyasu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Koji SekiguchiDepartment of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Hirotaka ShojiDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.
Tomoko ShindoElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Jumpei SasabeElectron Microscope Laboratory, Keio University School of Medicine, Tokyo, 160-8582, Japan.
Daiki TokuyasuDepartment of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Jin NakaharaDepartment of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Tsuyoshi MiyakawaDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Aichi, 470-1192, Japan.
Daisuke ItoDepartment of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. d-ito@jk9.so-net.ne.jp.

Funding

Japan Society for the Promotion of Science 21H02812 and JP22H04922MEXT Promotion of the Distinctive Joint Research Center Program FY2021-2023 and JPMXP0621467949
6 · The paper itself

Abstract

backgroundMicroglia remodel neuronal circuits in pathological conditions; however, the molecular requirements for these responses and their consequences for motoneuron survival remain unclear.

methodsAif1 (Iba1) knockout mice were generated using CRISPR/Cas9-mediated deletion, and baseline phenotypes and responses to unilateral facial nerve axotomy were assessed using immunohistochemistry, transmission electron microscopy, and single-nucleus RNA sequencing of the facial motor nucleus. Motoneuron survival and nuclear γH2AX foci were evaluated 28 days post-axotomy.

findingsUnder baseline conditions, Iba1

interpretationIba1 supports microglia-neuron cross-talk that enables effective perisomatic remodefling after axonal injury; disruption of this response is accompanied by inflammatory-state shifts and compromised motoneuron survival.

Indexed as

AxonsCalcium-Binding ProteinsFacial Nerve InjuriesMicrofilament ProteinsMicrogliaMotor NeuronsSynapsesAnimalsAxotomyCell SurvivalMaleMiceMice, Inbred C57BLMice, KnockoutAif1 protein, mouseCalcium-Binding ProteinsMicrofilament ProteinsFacial nerve axotomyIntegrated analysisMicrogliaMicroglia–neuron interactionNeuronal survivalSynaptic remodelingSynaptic stripping

Identifiers

PMID42098744
PMCPMC13321657

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.