ArticleBMC endocrine disorders2026
Diagnostic value of unilateral adrenal vein sampling with simple and biochemical/imaging correction: a study on early screening and typing for primary aldosteronism.
Article in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdrenal vein sampling (AVS) is the gold standard for distinguishing subtypes for primary aldosteronism. However, its technical challenges and frequent intubation failures pose difficulties. Our study aimed to establish diagnostic models for unilateral primary aldosteronism (UPA) to guide appropriate treatment in early patients.
methodsWe retrospectively analyzed 274 consecutive patients undergoing AVS without adrenocorticotropic hormone (ACTH) stimulated. We established a diagnostic model corrected by biochemical/imaging, and evaluated the diagnostic value of adrenal vein aldosterone/cortisol concentration (A/C) and its ratio to inferior vena cava (AV/IVC) before and after adjusted.
resultsIn a population with a median hypertension history of 3.5 years, the area under the curve (AUC) of adrenal vein A/C index for diagnosing ipsilateral and contralateral disease was 0.829 and 0.609, respectively. AUC of AV/IVC was 0.809 and 0.754, respectively. Factors like aldosterone concentration after saline infusion test (SIT), lowest blood potassium, and the presence of consistent adrenal gland nodules on CT were associated with UPA diagnosis, which were therefore included in the diagnostic models. The biochemical/imaging-corrected model correctly classified majority of patients (AUC: 0.828 - 0.893). For diagnosing ipsilateral aldosteronism, when 95% specificity achieved, sensitivities were 60% and 64% in A/C-adjusted and AV/IVC-adjusted models, respectively. As for diagnosing contralateral disease, when 95% specificity achieved, sensitivities were 50% and 53% in A/C-adjusted and AV/IVC-adjusted models, respectively.
conclusionsFor early primary aldosteronism patients, the integration of unilaterally adjusted AVS guided by biochemical and imaging indicators into clinical practice is feasible. While it does not play a definitive role, it provides valuable insights to support treatment decisions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.