ArticleBMC oral health2026
Preliminary in-vitro antibacterial evaluation of a novel formula of calcium phosphate nanoparticle-chlorhexidine intracanal medicament using confocal laser scanning microscopy.
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBacterial infection in root canals often persist despite thorough chemomechanical preparation. Conventional irrigants and medicaments reduce biofilms but have been accused of weakening dentin. Amorphous calcium phosphate nanoparticles showed promising results in enhancing dentin hardness, but the formula's anticmicrobial effect is yet to be evaluated in endodontic contexts. The aim of this study was to evaluate the feasibility of using 20% amorphous calcium phosphate nanoparticles loaded in chlorhexidine as an antibacterial intracanal medicament in endodontics.
methodsForty four root dentin discs were prepared from human extracted teeth, sterilized and inoculated with E. faecalis to establish a 3-week-old standard monospecies bacterial biofilm model. After confirming biofilm establishment, forty specimens were randomly divided into four groups (n = 10) according to the medicament used: 20% amorphous calcium phosphate nanoparticles loaded in 2% chlorhexidine (NACP + CHX), 2% chlorhexidine (CHX), calcium hydroxide (Ca(OH)
resultsAll test groups showed a statistically significant bacterial reduction, ranging from 36.81% to 59.19% (p ≤ 0.001). CLSM analysis showed that NACP + CHX and CHX had the highest antibacterial effect without a significant difference between them (p ≈ 0.9). Ca(OH)
conclusionThe findings suggest that NACP + CHX when used as an intracanal medicament, demonstrates antibiofilm efficacy against E. faecalis biofilm.
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