ArticleAnalytical and bioanalytical chemistry2026
Bromhexine screening using molecularly imprinted polymers for electrochemiluminescence detection and molecular recognition.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Electrochemiluminescence (ECL) is a highly sensitive detection technique; however, its inherently low selectivity is a significant challenge in analytical and sensing applications. In this study, we developed a system for the specific determination of the pharmaceutical bromhexine (BH). In this system, ECL was combined with a molecularly imprinted polymer (MIP) capable of molecular recognition. A BH-template-based MIP-modified electrode, synthesized by electrolytic polymerization, was prepared. Interestingly, the MIP-modified electrode robustly immobilized the template molecule via peroxidation during electrolytic synthesis. The sensitivity was approximately three times that without further oxidation. X-ray absorption fine structure measurements were performed using synchrotron radiation to characterize interactions between the analyte and the polymer. From the results, a complex mechanism involving hydrogen bonding, π-π interactions, and halogen-π interactions was inferred between the analytical chemical species and the polymer. The fabricated MIP-modified electrode was applied to determine BH in commercially available pharmaceuticals, prescription drugs, and biological urine samples. The results were compared with those from liquid chromatography-mass spectrometry. This system shows potential for development into a selective sensor.
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