Evidence map›Paper›PMID 42098504›Full record

ArticleNatural products and bioprospecting2026

First total synthesis of (±)-spirobroussonin B via electromediated oxidative coupling for constructing spirodienone ring.

Hong-Ji Shi, Xing-Ping Zhang, Cong-Xi Gao, Kun Xie, Wu-Yan Chen, Ming-Ming Li, Kou Wang

Abstract read
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In one paragraph

Article in Natural products and bioprospecting, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hong-Ji ShiSchool of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China.
Xing-Ping ZhangSchool of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China.
Cong-Xi GaoSchool of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China.
Kun XieSchool of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China.
Wu-Yan ChenSchool of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China.
Ming-Ming LiSchool of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming, 650500, China. lmm_xiaobai@126.com.ORCID http://orcid.org/0009-0001-2843-4244
Kou WangSchool of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Yunnan College of Modern Biomedical Industry, Kunming Medical University, Kunming, 650500, China. wangkou@kmmu.edu.cn.

Funding

Kunming Medical University Graduate Education Innovation Fund 2025S191Shanghai Municipal Commission of Science and Technology 23015821100Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps 202205AC160073
6 · The paper itself

Abstract

An electromediated oxidative coupling strategy for constructing spirodienone fragment has been developed and applied as the key step for the total synthesis of (±)-spirobroussonin B. This concise route was accomplished in only four steps, 41.6% overall yield and the key coupling reaction was demonstrated on a gram scale. The absolute configurations of the enantiomers were unambiguously determined by chiral resolution and ECD calculations. This work establishes a solid foundation for developing practical and efficient syntheses of spirobroussonin B and related analogues.

Indexed as

1,3-DiphenylpropaneElectromediatedSpirobroussonin BSpirodienone fragment

Identifiers

PMID42098504
PMCPMC13153339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.