Evidence map›Paper›PMID 42098502›Full record

ArticleThe Journal of antibiotics2026

Discovery of actinomycin derivatives with improved selectivity against malaria parasites from a Streptomyces culture library.

Aiko Teshima, Awet Alem Teklemichael, Asahi Hirata, Momoko Akimoto, Mayumi Taniguchi, Rukman Muslimin, Sho Ogaki, Alimuddin Ali, Toshihiro Suzuki, Shusaku Mizukami and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aiko Teshima *Program of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.
Awet Alem Teklemichael *Department of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.
Asahi HirataProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.
Momoko AkimotoProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.
Mayumi TaniguchiDepartment of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan.
Rukman MusliminProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.
Sho OgakiProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan.
Alimuddin AliDepartment of Biology, Universitas Negeri Makassar, Jl. Dg Tata Raya Parangtambung, Makassar, South Sulawesi, 90223, Indonesia.
Toshihiro SuzukiDepartment of Fermentation Sciences, Faculty of Applied Biosciences, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya, Tokyo, 156-8502, Japan.
Shusaku MizukamiDepartment of Immune Regulation, Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, Nagasaki, 852-8523, Japan. mizukami@nagasaki-u.ac.jp.
Kenji ArakawaProgram of Biotechnology, Graduate School of Integrated Sciences for Life, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima, 739-8530, Japan. karakawa@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0001-5129-0042

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 23108515, 25108718, 17H05446, and 19H04659
6 · The paper itself

Abstract

Our group explores the antimalarial compounds from the Streptomyces culture library. Pilot screening showed significant antimalarial activity in Streptomyces antibioticus HUT6035 (synonym of strain NBRC3117). We here isolated antimalarial compounds through large-scale fermentation and subsequent purification using chromatographies. Strain HUT6035 accumulated actinomycins X

Indexed as

AntimalarialsDactinomycinPlasmodium falciparumStreptomycesStreptomyces antibioticusFermentationHumansInhibitory Concentration 50AntimalarialsDactinomycin

Identifiers

PMID42098502
PMCPMC13310753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.