ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
From continuous to adaptive deep brain stimulation: Personalized modulation improves motor complications and sleep in Parkinson's Disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAdaptive deep brain stimulation (aDBS) dynamically modulates stimulation parameters in real time based on ongoing neural activity, potentially overcoming key limitations of conventional continuous DBS (cDBS) in Parkinson's disease (PD).
objectivesTo assess the impact of switching from cDBS to aDBS on motor and non-motor symptoms in PD patients with suboptimal cDBS outcomes.
methodsFour PD patients transitioned from optimized cDBS to aDBS using threshold algorithms tailored to beta-band activity. Motor and non-motor outcomes were assessed before surgery, under cDBS, and 9 months after aDBS using MDS-UPDRS parts I-IV, PDSS-2, and PDQ-39.
resultsaDBS reduced motor complications (ΔUPDRS-IV: -40.4%), while maintaining motor benefit. Patients showed improved sleep (ΔPDSS-2: -52.9%), improvement in non-motor and motor aspects of daily-living (ΔUPDRS-I: -43.6%; ΔUPDRS-II:- 31.3%), and quality-of-life (ΔPDQ-39: -24.7%). No adverse effects occurred and all patients preferred aDBS over cDBS.
conclusionsaDBS was feasible, well tolerated, and improved motor fluctuations and sleep quality compared with cDBS, supporting its role in personalized neuromodulation for PD.
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