Evidence map›Paper›PMID 42098464›Full record

ArticleInternational journal of clinical oncology2026

Survival outcomes of the patients with advanced laryngeal squamous cell carcinoma treated with chemoradiotherapy and total laryngectomy based on reports of head and neck cancer registry of Japan.

Yuta Yamamura, Yuto Horichi, Tatsuya Furukawa, Hirotaka Shinomiya, Megumi Kitayama, Daisuke Kawakita, Takeshi Kodaira, Munenaga Nakamizo, Seiichi Yoshimoto, Ken-Ichi Nibu

Abstract read
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In one paragraph

Article in International journal of clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuta YamamuraDepartment of Otolaryngology-Head and Neck Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Yuto HorichiDepartment of Otolaryngology-Head and Neck Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Tatsuya FurukawaDepartment of Otolaryngology-Head and Neck Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Hirotaka ShinomiyaDepartment of Otolaryngology-Head and Neck Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. hshino@med.kobe-u.ac.jp.ORCID http://orcid.org/0000-0003-1667-7545
Megumi KitayamaClinical Study Support Center, Data Center Department, Wakayama Medical University Hospital, Wakayama, Japan.
Daisuke KawakitaDepartment of Otorhinolaryngology-Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Takeshi KodairaDepartment of Radiation Oncology, Aichi Cancer Center, Nagoya, Japan.
Munenaga NakamizoDepartment of Otorhinolaryngology-Head and Neck Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Seiichi YoshimotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Ken-Ichi NibuDepartment of Otolaryngology-Head and Neck Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRoles of induction chemotherapy (ICT) and chemoradiotherapy (CRT) for laryngeal preservation in patients with locally advanced laryngeal cancer (LC) remain unclear. PATIENTS AND

methodsWe enrolled 834 patients with T3N0-2M0 and T4aN0-2M0 LC registered in the Head and Neck Cancer Registry of Japan between 2011 and 2015. Oncological outcomes of total laryngectomy (TL), CRT, and ICT were evaluated. Propensity score-matching analyses (PSMA) were performed between TL and CRT, excluding ICT.

resultsNo significant differences were observed in overall survival (OS) and disease-specific survival (DSS) among patients treated by TL, CRT, and ICT followed by TL or CRT, and among patients treated by TL and CRT in PSMA. Of note, no significant difference was observed in LCR and LRFS between TL and ICT groups.

conclusionsICT and CRT did not yield survival benefits but might contribute to laryngeal preservation without compromising survival in patients with T3-4aN0-2M0.

Indexed as

Carcinoma, Squamous CellChemoradiotherapyHead and Neck NeoplasmsLaryngeal NeoplasmsLaryngectomyAdultAgedAged, 80 and overFemaleHumansInduction ChemotherapyJapanMaleMiddle AgedNeoplasm StagingRegistriesChemoradiotherapyHead and neck cancerInduction chemotherapyLaryngeal squamous cell carcinomaSurgery

Identifiers

PMID42098464
PMCPMC13303432

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.