Evidence map›Paper›PMID 42098417›Full record

Trial reportNature metabolism2026

Gut microbiota responses to bariatric surgery are associated with metabolic outcomes and type 2 diabetes remission.

Lisa M Olsson, Heidi Borgeraas, Rima M Chakaroun, Dag Hofsø, Jens Kristoffer Hertel, Chinmay Dwibedi, Matthias Mitteregger, Jens Juul Holst, Valentina Tremaroli, Jøran Hjelmesæth and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01778738 (Glycaemia, Insulin Secretion and Action in Morbidly Obese Subjects With Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01778738 nacompletednot on this map

Glycaemia, Insulin Secretion and Action in Morbidly Obese Subjects With Type 2 Diabetes After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Randomised Single Centre Study

TypeinterventionalSponsorSykehuset i Vestfold HFRan2013 to 2022Enrolled125ConditionsType 2 Diabetes, Morbid ObesityArmsBariatric surgery, either gastric bypass surgery or sleeve gastrectomy, Sleeve gastrecomy, Bastric bypass
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lisa M OlssonThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-9730-1915
Heidi BorgeraasDepartment of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tønsberg, Norway.
Rima M ChakarounThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-9901-1815
Dag HofsøDepartment of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tønsberg, Norway.
Jens Kristoffer HertelDepartment of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tønsberg, Norway.ORCID http://orcid.org/0000-0002-8693-7018
Chinmay DwibediThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-6416-4440
Matthias MittereggerThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-0703-6415
Jens Juul HolstNovo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6853-3805
Valentina TremaroliThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-9150-4233
Jøran HjelmesæthDepartment of Endocrinology, Obesity and Nutrition, Vestfold Hospital Trust, Tønsberg, Norway.ORCID http://orcid.org/0000-0002-1995-0562
Fredrik BäckhedThe Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Fredrik@wlab.gu.se.ORCID http://orcid.org/0000-0002-4871-8818

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 615362Fondation Leducq 17CVD01Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2017.0026Novo Nordisk Fonden (Novo Nordisk Foundation) METABASENovo Nordisk Fonden (Novo Nordisk Foundation) NNF13OC0008163Vetenskapsrådet (Swedish Research Council) 2013-07800Vetenskapsrådet (Swedish Research Council) 2018-05973Vetenskapsrådet (Swedish Research Council) 2022-06725
6 · The paper itself

Abstract

Bariatric surgeries, such as Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), improve obesity and type 2 diabetes (T2D). Both surgeries affect the gut microbiota, but their contribution to T2D remission remains unclear. In this subanalysis (RYGB, n = 39; SG, n = 38) of the randomized controlled Oseberg trial ( NCT01778738 ), in which participants underwent either RYGB or SG surgery, we profiled the faecal microbiome of individuals with obesity and T2D before and 12 months after surgery. We show that both surgeries altered the microbiome in the same direction, but with larger changes after RYGB. The SG-associated altered microbiome composition correlated positively with circulating glucagon-like peptide 1 levels, beta-cell function and 5 year T2D remission. Remission was also linked to increased gene richness and metabolic potential for fermentation, methanogenesis and butyrate production. Notably, these associations persisted after accounting for the extent of weight loss. Our findings indicate that surgery-specific microbial adaptations influence metabolic improvements and may help to explain heterogeneity in T2D remission after bariatric surgery.

Indexed as

Bariatric SurgeryDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeAdultFemaleGastric BypassHumansMaleMiddle AgedObesityRemission InductionTreatment OutcomeWeight Loss

Identifiers

PMID42098417
PMCPMC13218940

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.