Evidence map›Paper›PMID 42098379›Full record

ArticleNature cancer2026

A high-MAPK, low-WNT cell state drives metastatic dissemination in colorectal cancer.

Melanie Heinlein, Ginny X Li, Noelyn Kljavin, Amanda R Moore, Brian Biehs, Liming Tao, Soufiane Boumahdi, Farnaz Mohammadi, Minyi Shi, Yuxin Liang and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Melanie HeinleinDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Ginny X LiRoche Informatics, Hoffman-La Roche Canada, Mississauga, Ontario, Canada.
Noelyn KljavinDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Amanda R MooreDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3864-6387
Brian BiehsDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Liming TaoDepartment of Cell and Tissue Genomics, Genentech, South San Francisco, CA, USA.
Soufiane BoumahdiDepartment of Research Oncology, Genentech, South San Francisco, CA, USA.
Farnaz MohammadiComputational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA.
Minyi ShiDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Yuxin LiangDepartment of Proteomic and Genomic Technologies, Genentech, South San Francisco, CA, USA.
Hartmut KoeppenDepartment of Research Pathology, Genentech, South San Francisco, CA, USA.
Nicolò RiggiDepartment of Cell and Tissue Genomics, Genentech, South San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9160-1984
Robert PiskolComputational Sciences Center of Excellence, Genentech, South San Francisco, CA, USA. piskol.robert@gene.com.ORCID http://orcid.org/0000-0001-8942-9943
Frederic J de SauvageDepartment of Research Oncology, Genentech, South San Francisco, CA, USA. desauvage.fred@gene.com.ORCID http://orcid.org/0000-0002-5275-2584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC), a leading cause of cancer-related mortality due to distant metastases, is largely driven by activating mutations in the WNT and mitogen-activated protein kinase (MAPK) pathways. Understanding the mechanism underlying the metastatic process is essential for developing effective treatments. Using serial in vivo orthotopic passaging, we developed an immunocompetent mouse model of metastatic CRC. Highly metastatic tumor cells exhibited chromosomal amplifications in MAPK pathway genes, resulting in increased MAPK pathway activity and suppression of WNT-associated transcriptional programs, including stem cell genes. Pharmacological inhibition of mutant KRAS

Indexed as

Colorectal NeoplasmsLiver NeoplasmsMitogen-Activated Protein KinasesWnt ProteinsWnt Signaling PathwayAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMAP Kinase Signaling SystemMiceNeoplasm MetastasisMitogen-Activated Protein KinasesWnt Proteins

Identifiers

PMID42098379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.