Evidence map›Paper›PMID 42098348›Full record

ArticleEuropean journal of clinical pharmacology2026

Association between anticholinergic and sedative medications and physical functioning: data from the Canadian longitudinal study on aging (CLSA).

Keren Pelen, Patrick Boissy, Karina Lebel, Alexandra Mayhew, Marla K Beauchamp, Lauren E Griffith, Megan E O'Connell, Sarah N Hilmer, Marie-Laure Baroud, Caroline Sirois and 5 more

Abstract read
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In one paragraph

Article in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Keren PelenFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada.
Patrick BoissyFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada.
Karina LebelResearch Center on Aging, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC, Canada.
Alexandra MayhewDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Marla K BeauchampMcMaster Institute for Research on Aging, McMaster University, Hamilton, ON, Canada.
Lauren E GriffithDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Megan E O'ConnellDepartment of Psychology and Health Studies, University of Saskatchewan, Saskatoon, SK, Canada.
Sarah N HilmerKolling Institute, Northern Sydney Local Health District and Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Marie-Laure BaroudFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada.
Caroline SiroisFaculté de pharmacie, Université Laval, Québec, Canada.
Frank MoriartySchool of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Leinster, Ireland.
Jean-Philippe TurcotteResearch Center on Aging, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC, Canada.
Lisa Kouladjian O'DonnellKolling Institute, Northern Sydney Local Health District and Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Kathryn NicholsonDepartment of Epidemiology & Biostatistics, Western University, London, ON, Canada.
Benoit CossetteFaculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada. benoit.cossette@usherbrooke.ca.

Funding

CIHR ACD-192899CIHR LSA 94473
6 · The paper itself

Abstract

purposeThe cumulative use of anticholinergic and sedative medications has been associated with lower physical function in older adults. This study aimed to identify which physical function attributes are most impacted in subgroups aged 45-64 and 65-85 years.

methodsBaseline data from 30,097 community-living Canadians in the Canadian Longitudinal Study on Aging were analysed using a cross-sectional design. Anticholinergic and sedative medications use was quantified using the Drug Burden Index (DBI). Physical functioning was measured via the timed 4-meter walk, Timed Up and Go (TUG), single leg balance, chair rise and grip strength. Physical functioning profiles were generated using latent profile analysis of the five tests. Associations between DBI scores and physical functioning were assessed through linear regression and multinomial logistic regression.

resultsThe mean age of participants was 63.0, 50.9% were female, 18.3% had a DBI score 0 < DBI < 1 and 8.7% a DBI score ≥ 1. Adjusted regression models showed the greatest reduction in standardized scores for the TUG test among participants with DBI ≥ 1 (β: -6.05; -6.77 to - 5.33) relative to DBI = 0. Latent profile analysis indicated that the two profiles with the poorest physical functioning were associated with higher odds of exposure to 0 < DBI < 1 and DBI ≥ 1, whereas the profile reflecting the best functioning was associated with reduced odds of exposure to DBI ≥ 1. Associations of similar magnitude were observed across age strata (45-64 and 65-85 years).

conclusionCumulative anticholinergic and sedative medication burden was inversely associated with physical functioning. These findings were consistent across middle-aged and older adults.

Indexed as

Cholinergic AntagonistsHypnotics and SedativesAgedAged, 80 and overAgingCanadaCanadian Longitudinal Study on AgingCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedCholinergic AntagonistsHypnotics and SedativesAnticholinergicsCanadian longitudinal study on agingCLSAPhysical functioningSedatives

Identifiers

PMID42098348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.