Evidence map›Paper›PMID 42098309›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.

Adam J Krause, Raquel Osorno, Natalie L Solomon, Maryam Ahmadi, Pandora Lam, Olivia Magana, Emilija Blozyte-Sakenis, Leah N Harris, Madeline C Babros, Sarah S Izabel and 9 more

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04424407 (A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network to Treat Depression and Anxiety), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04424407 nacompletednot on this map

A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network to Treat Depression and Anxiety

TypeinterventionalSponsorStanford UniversityRan2021 to 2024Enrolled51ConditionsInsomnia, DepressionArmsCognitive Behavioral Therapy for Insomnia
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Adam J KrauseDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Raquel OsornoDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Natalie L SolomonDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Maryam AhmadiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Pandora LamDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Olivia MaganaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Emilija Blozyte-SakenisDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Leah N HarrisDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Madeline C BabrosDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Sarah S IzabelDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Rebecca A BernertDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Leanne M WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9987-7360
James J GrossDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3624-3090
Jun MaDepartment of Medicine, University of Illinois Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-7996-6454
Laura C LazzeroniDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1846-6920
Jerome A YesavageDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Rachel ManberDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Jared M SaletinDepartment of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0002-8547-0161
Andrea N Goldstein-PiekarskiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. agoldpie@stanford.edu.ORCID http://orcid.org/0000-0001-6382-4312

Funding

Youth suicide risk: interplay of sleep behavior and circadian timing with self-critical rumination and self- reassuranceP20GM139743 · NIGMS · EMMA PENDLETON BRADLEY HOSPITAL · PI Mary A Carskadon · 2021 to 2026
$13.0M
A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network and Treat Depression and AnxietyR33MH120245 · NIMH · STANFORD UNIVERSITY · PI Andrea Goldstein-Piekarski · 2024 to 2026
$2.9M
A Novel Use of a Sleep Intervention to Target the Emotion Regulation Brain Network and Treat Depression and AnxietyR61MH120245 · NIMH · STANFORD UNIVERSITY · PI GOLDSTEIN-PIEKARSKI, ANDREA · 2020 to 2021
$1.9M
NIGMS NIH HHS P20 GM139743NIMH NIH HHS R33 MH120245NIMH NIH HHS R61 MH120245U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) P20GM139743U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R61MH120245
6 · The paper itself

Abstract

Treating insomnia with Cognitive-Behavioral Therapy for Insomnia (CBT-I) improves depression symptoms, but the underlying mechanisms remain unknown. This single-arm mechanistic trial (ClinicalTrials.gov, NCT04424407) examined fronto-limbic and sleep mechanisms of CBT-I's antidepressant response in 48 participants (64% female; age 25-60) with insomnia and depression symptoms. Participants completed functional magnetic resonance imaging (fMRI), polysomnography (PSG), and symptom assessments before and after 6 CBT-I sessions. CBT-I resulted in reduced amygdala reactivity to fearful faces (d = 0.55, p = 0.008). Depression and sleep (objective and self-reported insomnia symptoms also improved. However, fMRI-assessed fronto-limbic changes were not associated with a reduction of depressive symptom severity. Instead, reduced depressive symptoms correlated with reduced self-reported insomnia symptoms (p = 0.001, η

Indexed as

Cognitive Behavioral TherapyDepressionFrontal LobeLimbic SystemSleepSleep Initiation and Maintenance DisordersAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPolysomnographyTreatment Outcome

Identifiers

PMID42098309
PMCPMC13268098

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.