Evidence map›Paper›PMID 42098266›Full record

Trial reportNature human behaviour2026

Population-based RCT of a digital cognitive-behavioural guided self-help intervention for anxiety, depression and eating disorders in college students.

Michelle G Newman, Ellen E Fitzsimmons-Craft, Seung Yeon Baik, Nur Hani Zainal, Adam Calderon, Gavin N Rackoff, Marie-Laure Firebaugh, Elsa Rojas-Ashe, Yan Leykin, Daphne Lew and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04162847 (Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04162847 nacompletednot on this map

Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations

TypeinterventionalSponsorWashington University School of MedicineRan2019 to 2023Enrolled6,205ConditionsAnxiety Disorders, Depressive Disorder, Eating DisordersArmsSilverCloud Health Intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michelle G Newman *Department of Psychology, The Pennsylvania State University, University Park, PA, USA. mgn1@psu.edu.ORCID http://orcid.org/0000-0003-0873-1409
Ellen E Fitzsimmons-Craft *Department of Psychological and Brain Sciences, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-7064-3835
Seung Yeon BaikDepartment of Psychology, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-0218-3889
Nur Hani ZainalDepartment of Psychology, National University of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-2023-3173
Adam CalderonDepartment of Psychology, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-3968-0715
Gavin N RackoffDepartment of Health Policy and Health Services Research, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3525-3975
Marie-Laure FirebaughDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3663-131X
Elsa Rojas-AsheCenter for m2Health, Palo Alto University, Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-8563-3696
Yan LeykinDepartment of Psychology, Palo Alto University, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-9851-0142
Daphne LewDepartment of Biostatistics, Washington University in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0001-5433-2367
Daniel EisenbergDepartment of Health Policy and Management, University of California-Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5597-7925
C Barr TaylorCenter for m2Health, Palo Alto University, Mountain View, CA, USA.ORCID http://orcid.org/0000-0002-4564-6548
Denise E WilfleyDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3599-8689

Funding

Harnessing Mobile Technology to Reduce Mental Health Disorders in College PopulationsR01MH115128 · NIMH · WASHINGTON UNIVERSITY · PI EISENBERG, DANIEL, NEWMAN, MICHELLE G · 2018 to 2022
$4.1M
Developing an Optimized Conversational Agent or "Chatbot" to Facilitate Mental Health Services Use in Individuals with Eating DisordersK08MH120341 · NIMH · WASHINGTON UNIVERSITY · PI FITZSIMMONS-CRAFT, ELLEN E. · 2019 to 2023
$824k
NEURAL REPRESENTATIONS OF MOTION DURING EYE MOVEMENTSF31MH012034 · NIMH · NEW YORK UNIVERSITY · PI CHUKOSKIE, LEANNE · 1998 to 1999
–
NIMH NIH HHS F31 MH012034NIMH NIH HHS K08 MH120341NIMH NIH HHS R01 MH115128U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K08 MH12034
6 · The paper itself

Abstract

Scalable approaches such as digital cognitive-behavioural therapy guided self-help (D-CBTgsh) may help close the treatment gap for college students with mental disorders. In a randomized clinical trial (ClinicalTrials.gov: NCT04162847) across 26 US colleges, populations were offered a mental health screen (39,194 assessed). Students with clinical levels or high risk for anxiety, depression and/or eating disorders (N = 6,205) were randomized to screening+D-CBTgsh or screening+referral-to-college-provided-care groups. Screening+D-CBTgsh reduced prevalence of any mental disorder (primary outcome) at 6 weeks (odds ratio (OR) = 0.80, 95% CI = 0.70-0.91), 6 months (OR = 0.77, 95% CI = 0.68-0.88) and 2 years (OR = 0.82, 95% CI = 0.72-0.93). Services uptake was greater in screening+D-CBTgsh (74.4%) versus screening+referral (30.2%) at 6 months (OR = 6.72, 95% CI = 6.01-7.52) and 2 years (OR = 1.83, 95% CI = 1.64-2.04), including for minoritized groups. Screening+D-CBTgsh (versus screening+referral to college-provided care) also improved dimensional outcomes of generalized anxiety, social anxiety, depression, eating disorder symptoms and mental health functioning. Findings supported transdiagnostic prevention and intervention benefits of screening+D-CBTgsh and its viability as a scalable, population-based approach.

Indexed as

AnxietyAnxiety DisordersCognitive Behavioral TherapyDepressionFeeding and Eating DisordersSelf CareStudentsAdolescentAdultFemaleHumansMaleUniversitiesYoung Adult

Identifiers

PMID42098266
PMCPMC13160235

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.