Evidence map›Paper›PMID 42098250›Full record

ArticleScientific reports2026

Prediction of SARS-CoV-2 exposure through T cell activation profiles.

Genevieve C Van de Bittner, Tatiana Paredes Santos, Israel Steinfeld, Brian J Peter, Kristin B Bernick, Kelly M Kroeger

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Genevieve C Van de Bittner *Agilent Research Laboratories, Agilent Technologies Inc., Santa Clara, CA, USA. genvdb@gmail.com.
Tatiana Paredes Santos *Agilent Research Laboratories, Agilent Technologies Inc., Santa Clara, CA, USA. tatiana.santos@agilent.com.
Israel SteinfeldAgilent Research Laboratories, Agilent Technologies Inc., Santa Clara, CA, USA.
Brian J PeterAgilent Research Laboratories, Agilent Technologies Inc., Santa Clara, CA, USA.
Kristin B BernickAgilent Research Laboratories, Agilent Technologies Inc., Santa Clara, CA, USA.
Kelly M KroegerAgilent Research Laboratories, Agilent Technologies Inc., Santa Clara, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the ongoing effort to study the SARS-CoV-2 virus and COVID-19 disease, assessment of the T cell immune response has guided vaccine and therapeutic development. T cell immunity, as measured by T cell activation, is commonly assessed by the activation induced marker (AIM) assay. However, no concerted effort has been made to compare AIM pairs and identify those that best detect T cell activation. The emergence of SARS-CoV-2 provided unique access to both known naïve and COVID-19 convalescent donor samples for the comparison of 35 unique T cell AIM pairs using a 15-marker flow cytometry panel. Detailed comparative analysis identified top performing AIM pairs and informed the development of a machine learning algorithm that predictively classified samples as COVID-19 convalescent or naïve. This approach may be additionally applicable to the assessment and prediction of T cell antigen reactivity in cancer and autoimmune disease.

Indexed as

COVID-19Lymphocyte ActivationSARS-CoV-2T-LymphocytesFlow CytometryHumansMachine Learning

Identifiers

PMID42098250
PMCPMC13341749

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.