Evidence map›Paper›PMID 42098242›Full record

ArticleScientific reports2026

A D-dimer and ADAMTS8 based multi-marker score for the diagnosis of acute aortic dissection.

Ting Tian, Liping Zhao, Xinxin Tian, Fen Liu, Qiang Zhao, Junyi Luo, Qian Zhao, Yanhong Li, Xiaomei Li, Yining Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting Tian *Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.
Liping Zhao *Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.
Xinxin TianDepartment of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.
Fen LiuState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Clinical Medical Research Institute, Xinjiang Medical University, Urumqi, 830054, China.
Qiang ZhaoDepartment of Cardiology, People's Hospital of Xinjiang Uygur Autonomous Region, 91 Tianshan Road, Urumqi, 830001, Xinjiang, China.
Junyi LuoDepartment of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.
Qian ZhaoDepartment of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.
Yanhong LiDepartment of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.
Xiaomei Li *Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China. lixm505@163.com.
Yining Yang *State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Clinical Medical Research Institute, Xinjiang Medical University, Urumqi, 830054, China. yangyn5126@163.com.

Funding

National Natural Science Foundation of China 82570503Natural Science Foundation of Xinjiang Uygur Autonomous Region 2022D01D22Natural Science Foundation of Xinjiang Uygur Autonomous Region 2024D01C108Tianchi Talent Cultivation Program Project of Xinjiang Uygur Autonomous Region 2025013Youth Project of Medicine and Technology of Health Commission of Xinjiang Uygur Autonomous Region WJWY-201419
6 · The paper itself

Abstract

Acute aortic dissection (AAD) is a life-threatening emergency without established effective monitoring biomarkers. This study aimed to explore biomarkers to optimize the diagnosis of AAD. AAD related genes were screened by spatial transcriptomics experiments, and their encoded proteins were validated in aortic tissues. We measured plasma levels of candidate proteins in 302 participants (173 AAD cases, 129 controls), finding higher PTMA, ADAMTS8, and CD36 in AAD. Case-control analysis revealed that elevated levels of those proteins along with D-dimer, increased systolic blood pressure (SBP), height and smoking history were risk factors for AAD. A multi-marker score comprising D-dimer, ADAMTS8, height, SBP, and age was developed for AAD diagnosis, achieving an AUC of 0.921 (95%CI 0.889-0.952), with 77.5% sensitivity and 96.5% specificity. We further validated the diagnostic performance of the multi-marker score in an independent validation set including healthy controls and patients with chest pain. Our findings indicate that PTMA, ADAMTS8, and CD36 are potential biomarkers associated with AAD. The multi-marker score effectively discriminates AAD from both healthy controls and non-AAD acute chest pain conditions, and may serve as a rapid, cost-effective auxiliary diagnostic tool.

Indexed as

ADAMTS ProteinsAortic DissectionFibrin Fibrinogen Degradation ProductsAcute DiseaseAdultAgedBiomarkersCase-Control StudiesCD36 AntigensFemaleHumansMaleMiddle AgedRisk FactorsADAMTS ProteinsBiomarkersCD36 AntigensFibrin Fibrinogen Degradation Productsfibrin fragment DAcute aortic dissectionDiagnostic biomarkerGene expressionMulti marker scoreRisk factors

Identifiers

PMID42098242
PMCPMC13156294

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