ArticleScientific reports2026
Prospective natural history and clinical biomarkers of EYS-associated retinopathy in the KEYS study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
EYS is one of the major causative genes of autosomal recessive retinitis pigmentosa, particularly in Asian, and is expected to be a key target for future therapies. However, reliable biomarkers have not established. This KEYS study aimed to evaluate whether structural and functional parameters could serve as potential biomarkers of disease progression in EYS-associated retinitis pigmentosa (EYS-RP). We prospectively observed 49 patients with EYS-RP at Kobe Eye Hospital over a 2-year period. Visual field testing was performed using the Humphrey Field Analyzer 10- 2 (HFA 10-2). The mean total deviation (TD) was divided into central and surrounding regions for analysis, and the mean deviation (MD) was also evaluated. Horizontal and vertical EZ widths were measured by OCT. Over 2 years, our study showed that visual field progressed in surrounding and central and horizontal EZ width decreased. In subgroup analysis, a decline in horizontal EZ width and correlations between visual field parameters and EZ width were observed only in the higher MD based on the mean baseline HFA-MD value. HFA and horizontal EZ width parameters may serve as useful biomarkers of disease progression in EYS-RP, although their effectiveness varies by disease severity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.