ArticleScientific reports2026
PD-L1-positive circulating tumor cells associate with tumor malignancy and impaired circulating immunity in patients with gastrointestinal tumors.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Effect of extracellular vesicles on malignant tumours: Mechanisms and clinical findings (Review).Oncology letters · 2026Review
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Immunotherapies such as anti-PD-L1 antibodies have transformed cancer treatment, but their effectiveness in gastrointestinal tumors remains limited. One reason may be the absence of reliable prognostic markers that can identify patients at risk and those likely to benefit from such therapies. Circulating tumor cells (CTCs) have therefore gained attention as potential clinical markers for assessing tumor burden and immune status. In this study, 105 patients with esophageal, gastric, or colorectal cancer were enrolled preoperatively. CTCs were isolated and enumerated from venous blood using CellSearch, and PD-L1 expression was assessed. Lymphocytes were enriched via Percoll gradient centrifugation and analyzed by multiparametric flow cytometry. Statistical associations were evaluated using Chi-square tests. CTCs were detected in 16.2% of patients, and among these, 35.3% exhibited PD-L1
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