ArticleNature communications2026
ZAT-DNA enables DNA data storage with molecular-layer non-replicability.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- ZAT-DNA enables DNA data storage with molecular-layer non-replicability.Nature communications · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in patterns of canonical adenine and noncanonical 2-aminoadenine. As DNA polymerases cannot distinguish adenine from 2-aminoadenine, polymerase-based amplification erases these patterns, enforcing molecular-layer non-replicability intrinsic to the base-pairing ambiguity. We validate ZAT-DNA for secure key storage, demonstrating error-free encoding, storage, and high-fidelity nanopore retrieval of 32-bit and 64-bit cryptographic keys. ZAT-DNA blocks polymerase-based copying and protects non-fungible tokens by preventing functional duplication. For larger datasets, we present a hybrid "Babel-DNA" architecture: multiple encrypted images are co-encoded in a single regular DNA pool, with each selectively decryptable only via its cognate, non-replicable ZAT-DNA key. This provides a practical framework for molecular access control, secure DNA-encoded databases, and scarce molecular tokens.
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