Evidence map›Paper›PMID 42098094›Full record

ArticleNature communications2026

Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels.

Mikhail Tarasov, Madison Ammon, Jan Otto Wirth, Christopher Hampton, Zoja Selimi, Rengasayee Veeraraghavan, Przemysław B Radwański

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mikhail TarasovThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0009-0004-9637-058X
Madison AmmonThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0009-0003-3853-9765
Jan Otto WirthAbberior Instruments GmbH, Göttingen, Germany.ORCID http://orcid.org/0000-0002-6471-9626
Christopher HamptonThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID http://orcid.org/0009-0004-7408-6131
Zoja SelimiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Rengasayee VeeraraghavanThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Przemysław B RadwańskiThe Frick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. pradwanski@unr.edu.ORCID http://orcid.org/0000-0002-0750-2308

Funding

Distinct Ion Channel Pools and Intercalated Disk Nanoscale Structure Regulate Cardiac ConductionR01HL165751 · NHLBI · OHIO STATE UNIVERSITY · PI Thomas Jeffrey Hund, Rengasayee Veeraraghavan · 2023 to 2026
$2.9M
Regulation and dysregulation of sodium channels by by calmodulinR01HL155378 · NHLBI · OHIO STATE UNIVERSITY · PI RADWANSKI, PRZEMYSLAW · 2021 to 2025
$2.5M
Defining Novel Mechanisms of Sudden Death in Dravet Syndrome: Dysregulation of Sodium Channels in the HeartR01NS121234 · NINDS · OHIO STATE UNIVERSITY · PI Przemyslaw Radwanski · 2022 to 2026
$2.1M
NHLBI NIH HHS R01 HL155378NHLBI NIH HHS R01 HL165751NINDS NIH HHS R01 NS121234U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL165751
6 · The paper itself

Abstract

Precise regulation of ion channel biophysics is an essential life process that governs electrical signaling in excitable tissues. Many ion channels, including voltage-gated Na

Indexed as

Cell MembraneVoltage-Gated Sodium ChannelsAnimalsBiophysical PhenomenaBiophysicsHEK293 CellsHumansIon Channel GatingMembrane PotentialsSodiumSodiumVoltage-Gated Sodium Channels

Identifiers

PMID42098094
PMCPMC13369509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.