ArticleBDJ open2026
Remineralization of early caries lesions by calcium hypophosphite in vitro: a surface microhardness study.
Article in BDJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Human Enamel Formation: A Scoping Review for Oral Health Professionals.Dentistry journal · 2026Review
- Calcium Hypophosphite: A New Active Ingredient for Biomimetic Oral Care.Biomimetics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis in vitro study used a pH cycling model to compare the caries remineralizing efficacy of toothpaste formulations containing calcium hypophosphite (CaP), hydroxyapatite (HAP), or sodium fluoride (NaF).
methodsBovine enamel blocks with plaque-induced initial caries lesions were randomized (n = 30/group) to toothpaste formulations containing 1% CaP, 20% HAP, 1% CaP+20% HAP, or 1450 ppm fluoride provided as NaF. Lesion-bearing samples were subjected to a 14-day remineralization using a pH-cycling model with daily regimen of three 2-min applications of toothpaste slurry (1:3 toothpaste: water), one 2-h acid exposure, and storage in artificial saliva for the rest of the day. Remineralization was quantified as change in surface microhardness (SMH) of each sample measured before and after toothpaste treatment and expressed as percent remineralization (%Rem). Statistical analyses included paired t tests for within-group changes and one-way ANOVA with Tukey's post hoc tests for between-group comparisons (α = 0.05).
resultsAll groups exhibited significant (paired t test, p < 0.001) increase in SMH from baseline, indicating remineralization. Combining CaP and HAP achieved significantly (ANOVA/Tukey's, p < 0.001) greater %Rem (89.7 ± 3.3) when compared with CaP alone (75.4 ± 5.5), HAP alone (62.4 ± 4.8), or NaF alone (60.3 ± 7.8). While %Rem achieved with CaP alone was significantly (p < 0.001) greater than that of HAP and NaF, there was no significant difference in %Rem between HAP and NaF.
conclusionThis in vitro study demonstrates that CaP alone, and in combination with HAP, increases enamel surface microhardness, confirming that CaP-based formulations are efficient strategies for the remineralization of early caries lesions.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.