Evidence map›Paper›PMID 42097980›Full record

ReviewEuropean journal of haematology2026

Mechanisms of Thrombocytosis in Iron-Deficiency Anemia.

João Vitor Facco, Diane S Krause, Sara T Olalla Saad

Abstract readReview
In one paragraph

Review in European journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

João Vitor FaccoHematology and Transfusion Medicine Center (Hemocentro), University of Campinas (UNICAMP), Campinas, SP, Brazil.
Diane S KrauseDepartment of Laboratory Medicine, Yale School of Medicine, Yale University, New Haven, Connecticut, USA.
Sara T Olalla SaadHematology and Transfusion Medicine Center (Hemocentro), University of Campinas (UNICAMP), Campinas, SP, Brazil.ORCID https://orcid.org/0000-0003-0809-8068

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 177757/2024-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 306882/2023-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/11135-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2025/05991-2
6 · The paper itself

Abstract

Iron-deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions. This review synthesizes current evidence on how iron deficiency influences megakaryocytic-erythroid balance, with emphasis on progenitor-level regulation, iron sensing pathways and downstream megakaryocyte maturation. We discuss experimental and clinical studies supporting compensatory hematopoietic responses under iron-deficient conditions and propose an integrated framework linking systemic iron status to altered platelet and erythroid output.

Indexed as

Anemia, Iron-DeficiencyThrombocytosisAnimalsBlood PlateletsHematopoiesisHumansIronMegakaryocytesSignal TransductionIronhematopoiesisiron‐deficiency anemiairon metabolismmegakaryocytic‐erythroid progenitorthrombocytosis

Identifiers

PMID42097980
PMCPMC13542968

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.