Observational studyVox sanguinis2026
Association between NT-proBNP and false-positive Coombs test in patients with heart failure and elevated NT-proBNP.
Observational study in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Association between NT-proBNP and false-positive Coombs test in patients with heart failure and elevated NT-proBNP.Vox sanguinis · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe human antiglobulin test or Coombs' test is a key tool in the diagnosis and classification of haemolytic anaemia and could present as falsely positive. A retrospective study has described that B-type natriuretic peptide (NT-proBNP), a biomarker used for heart failure (HF), could be an additional cause of false positives in the Coombs test. MATERIALS AND
methodsA prospective, observational, single-centre study was conducted in adult patients diagnosed with HF between October 2024 and March 2025 at a tertiary hospital. The Coombs' test was considered as false positive in cases in which the specificity of the test included immunoglobulin G (IgG), the subsequent elution yielded a negative result, and blood haemolysis parameters were within normal ranges.
resultsThirty-six patients were included, of whom nine (25%) had a false-positive Coombs test. These patients had significantly higher levels of NT-proBNP (10,825 pg/mL [2587-35,000] vs. 3314 pg/mL [278-11,856], p = 0.0076) and lower glomerular filtration rate (35.3 mL/min/1.73 m
conclusionThe results suggest that elevated NT-proBNP could also be a cause of false positives in the Coombs test.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.