Evidence map›Paper›PMID 42097649›Full record

ArticleBMJ open2026

Advancing sustainable medication use in healthcare: a Delphi study on (de)prescribing interventions.

Elisabeth Marissa Smale, Jiske Lianne van der Giessen, Cathelijne Willemijne Yvonne Appels, Emiel Leegwater, Marlieke Dietz, Patricia Maria Lucia Adriana van den Bemt, Saskia Coenradie, Rudolf Bertijn Kool, Henk-Frans Kwint, Erwin Ista and 1 more

Abstract read
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisabeth Marissa SmaleDepartment of Adult Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands e.smale@erasmusmc.nl.ORCID http://orcid.org/0000-0002-5207-8454
Jiske Lianne van der GiessenDepartment of Adult Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.
Cathelijne Willemijne Yvonne AppelsReumazorg Zuid West Nederland, Roosendaal, The Netherlands.
Emiel LeegwaterDepartment of Pharmacy, Radboud University Medical Centre, Nijmegen, The Netherlands.
Marlieke DietzDepartment of Internal Medicine, Alrijne Hospital Leiden, Leiden, The Netherlands.
Patricia Maria Lucia Adriana van den BemtDepartment of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, the Netherlands.
Saskia CoenradieDepartment of Pharmacy, Reinier de Graaf Gasthuis, Delft, The Netherlands.
Rudolf Bertijn KoolIQ Healthcare, Scientific Institute for Quality of Healthcare, Radboud University Medical Centre, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-3134-487X
Henk-Frans KwintSIR Institute for Pharmacy Practice and Policy, Leiden, The Netherlands.
Erwin IstaDepartment of Pediatric Surgery, Intensive Care Unit, Erasmus MC Sophia Kinderziekenhuis, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1257-3108
Nicole HunfeldDepartment of Adult Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify and prioritise the most appropriate (de)prescribing interventions in inpatient and outpatient hospital care to advance environmentally sustainable healthcare.

designA modified RAND Delphi study.

settingInpatient and outpatient hospital care in the Netherlands.

participantsThe Delphi panel consisted of 63 participants, comprising 36 physicians and 27 pharmacists working in Dutch hospitals. PRIMARY AND SECONDARY OUTCOME MEASURES: Consensus on the appropriateness of (de)prescribing interventions for frequently used medications in inpatient and outpatient hospital care to advance environmentally sustainable healthcare and the prioritisation of interventions per care setting (inpatient/outpatient) and intervention type (deprescribing/sustainable dosage form), culminating in a top 20.

results51 (de)prescribing interventions were identified for 18 medication classes, for which consensus on appropriateness was reached for 42 (82%). The top 20 highest ranked interventions were identified, starting with switching from intravenous to oral administration of paracetamol, stopping chronically used proton pump inhibitors without indication and initiating antibiotics orally in case of good bioavailability.

conclusionsMost (de)prescribing interventions were considered appropriate for advancing sustainable medication use, highlighting support for their potential implementation to reduce the environmental burden of healthcare.

Indexed as

Drug PrescriptionsPractice Patterns, Physicians'ConsensusDelphi TechniqueHumansNetherlandsPharmacistsDelphi TechniqueHospitalsImplementation SciencePharmacistsPhysiciansPrescriptions

Identifiers

PMID42097649
PMCPMC13157796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.