Evidence map›Paper›PMID 42097625›Full record

ArticlePediatrics2026

Malaria in Children at 9 US Hospitals: 2016-2023.

Sesh Alexander Sundararaman, Brianne Roper, Amy K F Davis, Karen L Hanze Villavicencio, Jonathan A Mayhew, Michelle L Wang, Nina L Tang, Vijaya L Soma, Ziyi Wang, Margaret E Feeney and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sesh Alexander SundararamanDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Brianne RoperDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Amy K F DavisDepartment of Pediatrics at UCSF, San Francisco, California.
Karen L Hanze VillavicencioDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jonathan A MayhewDepartment of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, Michigan.
Michelle L WangUniversity of Washington School of Medicine, Seattle, Washington.
Nina L TangDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas.
Vijaya L SomaNYU Grossman School of Medicine, New York, New York.
Ziyi WangDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Margaret E FeeneyDepartment of Pediatrics at UCSF, San Francisco, California.
Indi TrehanUniversity of Washington School of Medicine, Seattle, Washington.
Jill E WeatherheadDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas.
Chandy C JohnDepartment of Pediatrics, Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana.
Jeffrey S GerberDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Audrey R Odom JohnDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Funding

From inhibitors to enzymatic deficiencies: exploring alterations in erythrocyte glycolysis as an antimalarial strategy.K08AI193172 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI Sesh Alexander Sundararaman · 2025 to 2026
$374k
NIAID NIH HHS K08 AI193172
6 · The paper itself

Abstract

objectivesThis study set out to describe imported pediatric malaria in the United States over an 8-year period, including patient demographics, clinical outcomes, and risk factors for severe disease.

methodsA retrospective descriptive study of pediatric patients treated for malaria at 9 hospitals in the United States from 2016 to 2023 was conducted to analyze patient demographics, clinical outcomes, and risk factors for severe malaria.

resultsA total of 171 children were treated across the 9 US hospitals included in this study from 2016 to 2023. Most patients had traveled to West Africa to visit friends and relatives. Fever was the most common symptom recorded (90%), and most reported at least 1 abdominal symptom (66%). Thirty-two percent of patients were diagnosed with severe malaria. No deaths occurred. Delayed diagnoses were common (26%), occurred at similar rates across all hospitals in the study, and were a risk factor for severe malaria.

conclusionsDelayed diagnoses of travel-acquired malaria were common for pediatric patients presenting to hospitals in the United States and are associated with higher risk for severe malaria, which is associated with longer hospitalizations and increased morbidity. Chemoprophylaxis against travel-acquired malaria and prompt diagnosis of imported cases are crucial to improving patient outcomes.

Indexed as

MalariaAdolescentAntimalarialsChildChild, PreschoolDelayed DiagnosisFemaleHumansInfantMaleRetrospective StudiesRisk FactorsTravelUnited StatesAntimalarials

Identifiers

PMID42097625
PMCPMC13245568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.