Observational studyOsteoarthritis and cartilage2026
The association of CT-detected intra-articular calcification with MRI-detected effusion-synovitis and Hoffa-synovitis in knee OA: The Multicenter Osteoarthritis study.
Observational study in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
backgroundCT-detected intra-articular (IA) calcification from calcium crystal deposition is associated with worsening cartilage damage and knee pain in osteoarthritis (OA); whether there is associated joint inflammation is unclear. We studied the relation of CT-detected IA calcification to imaging evidence of inflammation (i.e., effusion-synovitis and/or Hoffa-synovitis) on knee MRI in middle-aged and older adults, focusing on tissue-specific relationships.
methodsParticipants from the Multicenter Osteoarthritis study with knee CTs and MRIs were included. Presence of IA calcification on CT was defined as Boston University Calcium Knee Score >0 in hyaline cartilage, meniscus, and capsule anywhere in the knee. Effusion-synovitis and Hoffa-synovitis were scored on MRI using MOAKS at baseline and two years later. We evaluated the relation of IA calcification (overall and in specific tissues) to presence of effusion-synovitis and/or Hoffa-synovitis longitudinally, using Poisson regression with generalized estimating equations, adjusting for age, sex, race, and body mass index.
resultsWe included 1669 participants with available knee CT and MRI (mean age 60.6±9 years, 56% female, mean BMI 28.5±5 kg/m
conclusionCT-detected IA calcification in various tissues was associated with the presence of joint inflammation on MRI over 2 years.
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