ReviewSeminars in neurology2026
Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.
Review in Seminars in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Abstract: Tremor disorders encompass heterogeneous syndromes with distinct clinical, electrophysiological, and pathophysiological characteristics. Parkinson's disease tremor typically presents as a unilateral 4 to 6 Hz rest tremor, with re-emergent postural components or pure postural in some, driven by abnormal pallido-thalamo-cortical (PTC) oscillations and modulated by cerebellar inputs. Essential tremor is characterized by bilateral 4 to 8 Hz kinetic >postural tremor with regular, rhythmic EMG bursts, reflecting dysfunction within the cerebello-thalamo-cortical (CTC) pathway. Tremor in dystonia is frequently unilateral, irregular, and position- or task-specific, 3 to 5 Hz oscillations superimposed on dystonic co-contractions; the rhythmic component arises from CTC disturbances, while jerky dystonia involves PTC abnormalities. Holmes tremor is a slow (2.5-5 Hz) proximal tremor combining rest, postural, and kinetic features, resulting from multiple brain substrates in globus pallidus internus, red nucleus, and/or cerebellum (PTC and CTC). Understanding the underlying circuitry (or network) dysfunctions which are convergent as well as divergent across tremor syndromes can improve diagnostic accuracy and guide individualized therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.