SynthesisThe journal of nutrition, health & aging2026
Effects of multidomain interventions on health outcomes in older adults: A systematic review and meta-analysis.
Synthesis in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rethinking exercise dose for cognitive ageing: a systematic review and meta-analysis of physical dose and cognitive-motor demands.Frontiers in psychology · 2026Pooled it
- Pragmatic cluster-randomised trial of a multidomain intervention to prevent hospital-acquired disability: the OPTIMAge-IT study protocol.BMC geriatrics · 2026Trial
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith rising global aging, healthcare systems face challenges from multimorbidity, functional decline, and cognitive impairment. Multidomain interventions offer a promising approach to promoting healthy aging. This systematic review and meta-analysis evaluated the effects of multidomain interventions (≥3 domains) on motor-functional, cognitive, and psychological outcomes in older adults without moderate/severe dementia.
methodsFollowing PRISMA guidelines, PubMed and Embase were searched up to April 30, 2024. Eligible studies included clinical trials or observational studies involving adults ≥60 years receiving multidomain interventions versus control/standard care. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated.
resultsThirty-eight studies (57 comparisons) were included (median age: 75.3 intervention, 75.1 control; >60% female). Intervention lasted 2-36 months (median 6.0). All studies targeted the physical domain, 78.9% cognitive, 81.6% nutritional, and 84.2% additional domains. Motor-functional outcomes improved significantly (e.g., Short Physical Performance Battery: SMD = 0.40, 95% CI 0.14 to 0.66; Cardiovascular Health Study frailty criteria: SMD = -0.14, 95% CI -0.23 to -0.05), with diminishing effects over time. Other indicators (e.g., handgrip strength), showed modest improvements. Cognitive improvements were limited to Montreal Cognitive Assessment (MoCA; SMD = 0.23, 95% CI 0.06 to 0.40). Psychological benefits included reduced depressive symptoms (Geriatric Depression Scale: SMD = -0.35, 95% CI -0.57 to -0.12). Effect estimates for Timed Up and Go and RBANS were attenuated in sensitivity analysis excluding high-risk-of-bias studies.
conclusionsMultidomain interventions improve motor-functional and psychological well-being. Moderate cognitive benefits are observed primarily using the MoCA. These findings support large-scale implementation in geriatric care and highlight the need for strategies to sustain long-term effectiveness.
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