ArticleTranslational oncology2026
Single-cell and spatial transcriptomic profiling of POU5F1 in Lung Adenocarcinoma: Dynamics, spatial niche, and prognosis via multi-algorithm ML.
Article in Translational oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPOU5F1 (OCT4), a core regulator of pluripotency, plays an important role in tumor stemness and immune microenvironment remodeling, yet its systematic function and mechanisms in lung adenocarcinoma (LUAD) remain incompletely elucidated.
methodsThis study integrated genetic causality inference, single‑cell and spatial transcriptomics, RNA velocity analysis, and multi‑algorithm machine learning to systematically investigate the role of POU5F1 in LUAD. Summary‑based Mendelian Randomization (SMR) was used to link GWAS with lung tissue eQTL data; single‑cell and spatial analyses characterized POU5F1
resultsPOU5F1 was genetically associated with lung cancer risk and enriched in malignant, stem‑like cell clusters. RNA velocity indicated progressive activation along pseudotime trajectories. Spatial transcriptomics confirmed the co‑localization of POU5F1
conclusionPOU5F1 promotes LUAD progression by maintaining stemness, reprogramming CAFs, and shaping immune evasion, representing a promising biomarker and therapeutic target.
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