Evidence map›Paper›PMID 42096900›Full record

ArticlePoultry science2026

Organic acids and microencapsulated phenolic compounds in diets for laying hens.

Paloma Eduarda Lopes de Souza, Adiel Vieira de Lima, Carlos Henrique do Nascimento, Aline Beatriz Rodrigues, Amanda Fabrício Dantas de Lima, Cleber Franklin Santos de Oliveira, Edijanio Galdino da Silva, Apolônio Gomes Ribeiro, Ricardo Romão Guerra, Danilo Teixeira Cavalcante and 5 more

Abstract read
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paloma Eduarda Lopes de SouzaDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.
Adiel Vieira de LimaDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.
Carlos Henrique do NascimentoDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.
Aline Beatriz RodriguesDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.
Amanda Fabrício Dantas de LimaDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.
Cleber Franklin Santos de OliveiraDepartment of Statistics, Federal University of Alfenas (UNIFAL-MG), Rua Gabriel Monteiro da Silva, 700, Centro, Alfenas, MG, Brazil.
Edijanio Galdino da SilvaDepartment of Veterinary Sciences, Federal University of Paraíba (UFPB), Areia, PB, Brazil.
Apolônio Gomes RibeiroDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.
Ricardo Romão GuerraDepartment of Veterinary Sciences, Federal University of Paraíba (UFPB), Areia, PB, Brazil.
Danilo Teixeira CavalcanteDepartment of Animal Science, Federal University of Agreste of Pernambuco, Bom Pastor Avenue, no number, Boa Vista, Garanhuns, PE, 55292-270, Brazil.
Isabelle Naemi KanekoDepartment of Animal Science, Federal University of Rondônia (UNIR), Brazil.
Andreia MassuquettoTectron - Technology and Innovation, Toledo, PR, 85902-010, Brazil.
Thiago Pereira RibeiroTectron - Technology and Innovation, Toledo, PR, 85902-010, Brazil.
Lucas Rannier Ribeiro Antonino CarvalhoDepartment of Physiology and Pharmacology, Karolinska Institutet, Biomedicum 5B, Solnavägen 9, S-171 77, Stockholm, Sweden. Electronic address: lucas.carvalho@ki.se.
Fernando Guilherme Perazzo CostaDepartment of Animal Science, Federal University of Paraiba, Highway PB-079, Areia, PB, 58397-000, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the effects of dietary supplementation with microencapsulated organic acids and phenolic compounds in laying hens. The experiment was conducted with 500 Novogen Brown laying hens from 30 weeks of age. Birds were assigned to five treatments with 10 replicates of 10 birds each in a completely randomized design. The treatments consisted of: CD = control diet; 200AD1 = 200 g/t additive 1; 500AD1 = 500 g/t additive 1; 200AD2 = 200 g/t additive 2; and 500AD2 = 500 g/t additive 2. Productive performance, egg quality, organ pH and relative organ weight, intestinal histomorphometry, and serum biochemical parameters were evaluated. Treatment means were compared using the Tukey test at a 5% significance level. Dietary supplementation affected productive performance, egg quality, gastrointestinal morphology, and selected serum biochemical indicators. Birds receiving 500AD1 and 500AD2 showed higher egg production compared with those receiving 200AD2, whereas egg weight was lower in 500AD2 compared with 200AD1. Egg quality traits were also influenced, with greater eggshell thickness observed in 200AD2 and improved yolk index in 200AD2 and 500AD2 compared with the control diet. Relative weights of digestive organs, including gizzard, small intestine, pancreas, and proventriculus, were generally higher in birds receiving 200AD2. Cecal pH was reduced in 500AD1 compared with the other treatments. Intestinal histomorphometry showed significant alterations in villus structure, absorptive area, and goblet cell counts across intestinal segments, with 500AD2 frequently associated with higher villus:crypt ratios and greater ileal villus height. Serum biochemical parameters were also affected, including uric acid, γ-glutamyl transferase, calcium, and phosphorus. In summary, supplementation with microencapsulated organic acids and phenolic compounds modulated productive performance, egg quality, and intestinal physiology in laying hens. Higher inclusion levels, particularly 500AD2, were associated with more favorable intestinal morphometric responses and productive outcomes, whereas 200AD2 appeared to promote structural adaptations of the gastrointestinal tract. These findings highlight the potential of microencapsulated acidifier phytogenic blends as nutritional strategies to support intestinal functionality and productive efficiency in laying hens.

Indexed as

ChickensPhenolsAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsDietDietary SupplementsDose-Response Relationship, DrugFemaleOvumRandom AllocationPhenolsAntioxidantsEncapsulationIntestinal healthNatural additives

Identifiers

PMID42096900
PMCPMC13156626

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.