Evidence map›Paper›PMID 42096055›Full record

ArticleArchives of virology2026

Complete genome and phylogenetic characterization of a novel papillomavirus from Cuniculus paca in the Brazilian Amazon.

Cleyton Silva de Araújo, Laura Gabrielly Alves Henrique, Hanna Gabriela da Silva Oliveira, Jhonatan Henrique Lima da Rocha, Junio Damasceno de Souza, Agnes de Souza Lima, Vania Maria França Ribeiro, Francisco Carlos da Silva, David Driemeier, Cláudio Wageck Canal and 4 more

Abstract read
In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cleyton Silva de Araújo *Laboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0001-9273-7322
Laura Gabrielly Alves Henrique *Laboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0009-0005-8045-6351
Hanna Gabriela da Silva OliveiraLaboratório de Medicina Veterinária Preventiva e Vacinologia, Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal, 68740-970, PA, Brazil.ORCID http://orcid.org/0000-0003-2222-0680
Jhonatan Henrique Lima da RochaLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0001-6495-5082
Junio Damasceno de SouzaLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0001-9282-221X
Agnes de Souza LimaLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0001-6894-0929
Vania Maria França RibeiroLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0002-6904-2415
Francisco Carlos da SilvaLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0003-4105-3806
David DriemeierSetor de Patologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, Prédio 42.505, Porto Alegre, 9090, 91540-000, RS, Brazil.ORCID http://orcid.org/0000-0003-3766-0654
Cláudio Wageck CanalLaboratório de Virologia, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, Prédio 42.505, Porto Alegre, 9090, 91540-000, RS, Brazil.ORCID http://orcid.org/0000-0002-0621-243X
John MundaySchool of Veterinary Science, Massey University, Palmerston North, 4410, New Zealand.ORCID http://orcid.org/0000-0002-4769-5247
Felipe Masiero SalvaraniLaboratório de Medicina Veterinária Preventiva e Vacinologia, Instituto de Medicina Veterinária, Universidade Federal do Pará, Castanhal, 68740-970, PA, Brazil. felipems@ufpa.br.ORCID http://orcid.org/0000-0002-7711-6437
Flavio Roberto Chaves da SilvaLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil.ORCID http://orcid.org/0000-0002-1345-5413
Cíntia DaudtLaboratório de Virologia Geral e Parasitologia, Centro de Ciências Biológicas e da Natureza, Universidade Federal do Acre, Campus Universitário, BR 364, Km 04-Distrito Industrial, Rio Branco, 69920-900, AC, Brazil. cintia.daudt@ufac.br.ORCID http://orcid.org/0000-0002-0795-3934

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wild rodents remain underrepresented in papillomavirus genomics, limiting current understanding of host range, tissue tropism, and evolutionary diversity. Here, we report the first papillomavirus identified in the spotted lowland paca, Cuniculus paca, from the Brazilian Amazon, provisionally designated Cuniculus paca papillomavirus 1 (CpPV1). Histopathological examination supported the diagnosis of a virally induced squamous papilloma. Broad-range L1 PCR (FAP59/64), rolling-circle amplification, and Illumina MiSeq sequencing enabled recovery of a complete circular genome of 8,803 bp containing the canonical early (E6, E7, E1, and E2) and late (L2 and L1) open reading frames, together with a typical long control region. Pairwise comparison of the complete L1 gene showed 63.10% nucleotide identity to Erethizon dorsatum papillomavirus 2 (EdPV2), well below the threshold used for papillomavirus type demarcation. Maximum-likelihood phylogenetic analysis recovered CpPV1 as a distinct lineage sister to EdPV2 within a broader, non-monophyletic rodent papillomavirus assemblage. This finding expands the known diversity of Papillomaviridae in Neotropical rodents and provides new insight into papillomavirus evolution in an under-sampled host group.

Indexed as

Genome, ViralPapillomaviridaePapillomavirus InfectionsPhylogenyAnimalsBrazilDNA, ViralOpen Reading FramesSequence Analysis, DNADNA, ViralAmazon biomeCuniculus pacaGenome characterizationPapillomaviridaePhylogenyRodent virus

Identifiers

PMID42096055
PMCPMC13152935

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.