Evidence map›Paper›PMID 42096036›Full record

ArticleClinical journal of gastroenterology2026

Perihepatic dedifferentiated liposarcoma mimicking IgG4-related disease.

Soushi Shibusawa, Yuki Yamashita, Tomoyuki Tanaka, Takefumi Kimura, Shusei Sano, Hisashi Tamada, Yusuke Oka, Yoshiki Ozawa, Hiromitsu Mori, Shuichi Wada

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Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Soushi ShibusawaDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan.
Yuki YamashitaDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan. yukiyama@shinshu-u.ac.jp.ORCID http://orcid.org/0000-0002-0162-4208
Tomoyuki TanakaDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan.
Takefumi KimuraDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Shusei SanoDepartment of Hepatobiliary and Pancreatic Surgery, Nagano Red Cross Hospital, Nagano, Japan.
Hisashi TamadaDepartment of Pathology, Nagano Red Cross Hospital, Nagano, Japan.
Yusuke OkaDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan.
Yoshiki OzawaDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan.
Hiromitsu MoriDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan.
Shuichi WadaDepartment of Gastroenterology, Nagano Red Cross Hospital, 5-22-1 Wakasato, Nagano, 380-8582, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDedifferentiated liposarcoma (DDLPS) may originate in perihepatic adipose tissue, but can radiologically present as a hepatic mass. Moreover, dense Immunoglobulin G4 (IgG4)-positive plasma cell infiltration may mimic IgG4-related disease (IgG4-RD) and delay curative-intent resection. We herein describe a unique case that exemplifies this diagnostic pitfall. CASE PRESENTATION: A 67-year-old woman was incidentally found to harbor a hepatic mass in segment 6 along with small mesenteric nodules. Cross-sectional imaging showed heterogeneous non-fat containing lesions, while needle biopsy revealed abundant IgG4-positive plasma cells. Prednisolone treatment was commenced for presumed IgG4-related inflammatory pseudotumor. Although the lesions initially shrank slightly, they both enlarged during steroid tapering. Segment 6 hepatectomy with limited bowel resection was subsequently performed. Pathohistological examination revealed atypical stromal cells arising in perihepatic adipose tissue, and Mouse double minute protein 2 (MDM2) amplification confirmed liposarcoma infiltration into the liver and mesentery. Following the discontinuation of steroids, the patient has remained recurrence-free for fourteen months after surgery.

conclusionDDLPS can masquerade as IgG4-RD and even show temporary steroid responsiveness. When clinical or imaging treatment findings are atypical, comprehensive tissue evaluation with molecular analysis is essential to prevent diagnostic delay.

Indexed as

Immunoglobulin G4-Related DiseaseLiposarcomaLiver NeoplasmsAgedDiagnosis, DifferentialFemaleHepatectomyHumansImmunoglobulin GImmunoglobulin GDedifferentiated liposarcomaIgG4-related diseaseSteroid

Identifiers

PMID42096036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.