ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026
Inonotus obliquus polysaccharides alleviate UVB-irradiated skin photodamage by regulating calcium homeostasis through endoplasmic reticulum-mitochondria crosstalk.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
Funding
Abstract
Skin photodamage is closely related to mitochondrial dysfunction, and endoplasmic reticulum (ER) stress can induce excessive mitochondrial reactive oxygen species (ROS) accumulation, triggering inflammation, and inducing cell apoptosis. Polysaccharides from Inonotus obliquus (IOP) have antioxidant, anti-inflammatory, and immunomodulatory activities. Previous research has shown that IOP could significantly inhibit ultraviolet radiation B (UVB) induced ROS generation and apoptosis in skin cells, increase mitochondrial membrane potential and reduce the expression of ERS marker. However, the molecular mechanism has not yet been elucidated. This study used network pharmacology to analyze potential regulatory targets and explored the mechanism of IOP in alleviating UVB-induced photodamage by systematic experiments. Through network pharmacology analysis of targets related to ER, mitochondria and photodamage, it was found that core targets were concentrated in autophagy, inflammation, calcium ion (Ca
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Registered trials
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