Evidence map›Paper›PMID 42096011›Full record

ArticleBrain imaging and behavior2026

A cross-sectional and longitudinal study of changes in complex networks related to brain function in temporal lobe epilepsy patients treated with levetiracetam intervention therapy.

Cuimi Luo, Chuanyong Qu, Zirong Chen, Dongying Huang, Xiaomin Pang, Guiming Weng, Huachun Huang, Zhuoyan Qiu, Bailing Qin, Jinou Zheng

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In one paragraph

Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cuimi Luo *Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Chuanyong Qu *Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Zirong ChenDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Dongying HuangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Xiaomin PangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Guiming WengDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Huachun HuangDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Zhuoyan QiuDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Bailing QinDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Jinou ZhengDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China. jinouzheng@163.com.

Funding

National Natural Science Foundation of China,China 81560223
6 · The paper itself

Abstract

The aim of this study was to investigate the changes in complex networks of brain functions associated with LEV treatment and the neural mechanisms underlying the effects on executive functions. Patients with TLE, including both users and nonusers of LEV, were included in this study along with healthy controls. Rs-fMRI and an attentional network test (ANT) were performed, and 9 of the 23 patients not taking LEV were selected for LEV intervention and followed up for 18 months. Rs-fMRI and ANT were reviewed, and graph theoretic analyses were applied to investigate the changes in their topological properties. Both the LEV and HC groups showed improvements in executive function compared with the non-LEV group. At the global level, significant group differences in global efficiency and characteristic path length were observed among the three groups. At the nodal level, compared with the HC and non-LEV groups, the LEV group presented multiple differential nodes with different topological properties in the parieto-occipital lobe and frontal lobe. The TLE-LEV group had multiple differential nodes in the parieto-occipital lobe and frontal-temporal lobe compared with the TLE-N group. Notably, the LEV group's betweenness centrality of the superior frontal gyrus and dorsolateral and executive functions was significantly positively correlated with the correlation analyses. Changes in the topological properties are a key effect of LEV administration. This finding improves our understanding of the neural mechanisms by which LEV improves cognitive functioning.

Indexed as

AnticonvulsantsBrainEpilepsy, Temporal LobeLevetiracetamAdultAttentionCross-Sectional StudiesExecutive FunctionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeural PathwaysAnticonvulsantsLevetiracetamComplex brain networkGraph theoryLevetiracetamLongitudinal studyTLE

Identifiers

PMID42096011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.