Selenized Probiotic L. brevis 23017 Alleviates Colitis by Modulating the Nrf2-GPX4 Axis to Inhibit Ferroptosis.

Yuxin Zhuang, Qiuju Liu, Fangfei Shi, Rui Kong, Chunli Ma, Dexing Ma

Abstract read

In one paragraph

Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuxin ZhuangCollege of Veterinary Medicine, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China.

Qiuju LiuCollege of Veterinary Medicine, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China.

Fangfei ShiCollege of Veterinary Medicine, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China.

Rui KongCollege of Veterinary Medicine, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China.

Chunli MaCollege of Food Science, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China. machunli@neau.edu.cn.

Dexing MaCollege of Veterinary Medicine, Northeast Agricultural University, No.600 Changjiang Road, Xiangfang District, Harbin, 150030, China. madexing@neau.edu.cn.

Funding

Nature Science Foundation of Heilongjiang Province, China. LH2024C031

6 · The paper itself

Abstract

Ulcerative colitis (UC) constitutes a principal subtype of inflammatory bowel disease (IBD) and exhibits escalating global incidence. This study elucidates the therapeutic efficacy and mechanistic basis of novel selenized probiotic, Lactobacillus brevis 23017 (Se-Lb23017), and biogenic selenium nanoparticles (SeNPs) in a dextran sodium sulfate (DSS)-induced colitis murine model. The investigation specifically probed ferroptosis inhibition and activation of the Nrf2-GPX4-HO-1 signaling axis. The results demonstrated 80 µg/mL of Na

Indexed as

ColitisFerroptosisLevilactobacillus brevisNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseProbioticsSeleniumAnimalsDextran SulfateMaleMiceMice, Inbred C57BLDextran Sulfateglutathione peroxidase 4, mouseNfe2l2 protein, mouseNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseSeleniumAntioxidant pathwayFerroptosisL. brevis 23017Selenium nanoparticlesUlcerative colitis

Identifiers

PMID42095958

DOI10.1016/j.semcancer.2021.06.003

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.