ArticleNeuroradiology2026
IDH status shapes glioma oncotopy: voxel-wise mapping of 644 adult diffuse gliomas.
Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to characterize the anatomical and imaging features of adult-type diffuse gliomas across histomolecular subtypes.
methodsClinical 3-Tesla brain MRI images from 644 patients with pathologically confirmed adult-diffuse glioma before treatment was retrospectively evaluated: 527 IDH-wildtype glioblastoma, 71 astrocytoma, and 46 oligodendroglioma. Pre- and post-contrast T1-weighted, T2-weighted and FLAIR sequences were part of the MRI protocol. Contrast-enhancing tumors and non-enhancing lesions (NEL) were automatically segmented using HD-GLIO. We used a voxel-wise Fisher-exact-test followed by random-permutation (ADIFFI) to identify regions with higher occurrence of tumor associated with IDH-mutation status or 1p/19q-codeletion status. Mann-Whitney-U-test was used to compare signal intensities in CET and NEL across the three different subtypes of adult-diffuse glioma investigated here.
resultsWe observed a significant correlation of IDH-mutant gliomas with a predominance in the frontal lobe adjacent to the rostral extension of the lateral ventricles. IDH-wildtype tumors had larger NEL volumes than IDH-mutant gliomas (p < 0.0001). Signal intensity analysis demonstrated consistently lower T1w and T1-CE values and higher T2w and FLAIR values in IDH-mutant gliomas (all p < 0.0001). Oligodendrogliomas showed higher signal intensity on T1-CE images compared to astrocytomas (p = 0.035).
conclusionWe analyzed a large radio-genomic patient cohort consisting of glioblastoma, astrocytoma and oligodendroglioma. Our findings are in line with previously analyzed smaller patient cohorts. Our findings underline the importance of the IDH-mutation for determining tumor location and potentially point to a cell of origin along the rostral extension of the lateral ventricles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.