ArticleClinical neuroradiology2026
Continuation or Withdrawal of Life-sustaining Therapies After Acute Anoxic Events in Childhood and Adolescence : Can Early MRI Predict Particularly Severe Outcomes?
Article in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWithholding or withdrawing life-sustaining therapies is often discussed when children or adolescents suffer severe anoxic events. Previous studies have demonstrated that early MRI can identify patients with major neurological sequelae, but not whether, within a cohort with major neurological sequelae, early MRI can predict particularly severe outcomes. This was the purpose of the present study.
methodsWe retrospectively assessed MRI (analyzing 14 brain regions for signal abnormalities on diffusion, T1, T2 and FLAIR) of 38 patients who had suffered acute anoxic events between 8 months and 17 years of age and had required inpatient neurorehabilitation, looking for differences between patients with "particularly severe outcomes" (the 22/38 patients who were still unable to interact with their environment 22 weeks after the event) and patients with "less severe outcomes" (the 16/38 patients who had regained this ability within 22 weeks).
resultsPrediction of "particularly severe outcome" was optimal using diffusion MRI obtained on days 4-5 after the event (available in 11 patients, 7 with particularly severe outcomes), when all patients with diffusion restrictions in any of the following regions-putamen (4/7), caudate nucleus (4/7), globus pallidus (6/7), or substantia nigra (4/7)-later showed particularly severe outcomes. In contrast, identification of "less severe outcome" was optimal using MRI obtained between days 6-9 after the event, when absence of diffusion restrictions in the cerebral white matter always predicted "less severe outcome".
conclusionEarly MRI can identify patients with particularly severe outcomes-and thus can contribute to discussions about the continuation or withdrawal of life-sustaining therapies in the acute phase after anoxic events.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.