Observational studyEpilepsia2026
Quantitative electroencephalographic measures during postmalarial epileptogenesis.
Observational study in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
objectiveSevere malaria with neurologic involvement contributes significantly to the global burden of acquired pediatric epilepsy. We studied quantitative electroencephalographic (EEG) measures in postmalarial epileptogenesis.
methodsA total of 186 patients, aged 6 months to 11 years, with confirmed central nervous system malaria were enrolled in a prospective observational study conducted in Chipata, Zambia. EEG data were collected during acute illness for 179 patients. Patients were followed for 12 months postdischarge with EEG and clinical reviews to assess postmalarial epilepsy (PME) outcomes. A total of 155 patients were seen for 1-month, 144 for 6-month, and 142 for 12-month follow-up. Twenty-six patients were diagnosed with PME. We examined EEG measures (relative power, magnitude-squared coherence [MSC], and approximate entropy [ApEn]) to identify differences between patients who developed PME and those who did not.
resultsRelative gamma power at admission was significantly greater in the PME group, whereas at 1-month and 6-month follow-up it was greater in the nonepilepsy group. Alpha and beta power increased in both groups over time, suggesting a prolonged process of neurologic recovery, with greater power in both bands observed in the nonepilepsy group at 12-month follow-up. ApEn was greater in the nonepilepsy group at admission and 1-month and 6-month follow-up. At admission and 1-month follow-up, we observed a significant decrease in beta and gamma MSC in the epilepsy group as compared to the nonepilepsy group. These differences were absent at 6-month follow-up but became more prominent again at 12-month follow-up. SIGNIFICANCE: These and related EEG measures may provide value for risk stratification of patients with severe malaria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.