Evidence map›Paper›PMID 42095761›Full record

ArticleJournal of the American Chemical Society2026

Quaternary Carbons from Amines and Acids.

Ruheng Zhao, Shengchun Wang, Pingsen Shi, Sandip Kumar Das, Sijing Meng, Aiwen Lei, Tim Cernak

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruheng ZhaoDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Shengchun WangDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0003-3038-3404
Pingsen ShiThe Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.
Sandip Kumar DasDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Sijing MengDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Aiwen LeiThe Institute for Advanced Studies (IAS), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.ORCID 0000-0001-8417-3061
Tim CernakDepartment of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-5407-0643

Funding

New Amine-Acid Couplings and Their Impact on Medicinal PropertiesR01GM144471 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CERNAK, TIMOTHY · 2022 to 2025
$1.6M
NIGMS NIH HHS R01 GM144471
6 · The paper itself

Abstract

Carbon-carbon bonds are the most frequently encountered bonds in drugs, natural products, agrichemicals, and perfumes. This makes reactions that can access C-C bonds, particularly those that access sterically complex architectures, of high impact to multiple industries and applications. Common C-C bond-forming reactions such as the Suzuki coupling or Diels-Alder cycloaddition have revolutionized synthesis, yet the building blocks required to perform these reactions, such as boronic acids or dienes, are only available in modest diversity from commercial suppliers compared to other common building blocks. A reaction that makes densely functionalized C-C bonds from broadly available starting materials would facilitate deeper access into chemical space. Here, we demonstrate an sp

Identifiers

PMID42095761
PMCPMC13195652

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.