Evidence map›Paper›PMID 42095757›Full record

ArticleWorld journal of surgery2026

Relationship Between Radiographic and Pathological Portal Vein-Superior Mesenteric Vein Involvement in Neoadjuvant Treatment for Pancreatic Cancer: A Comparative Study of Neoadjuvant Chemotherapy and Chemoradiotherapy.

Naoko Sekiguchi, Hidenori Takahashi, Hirofumi Akita, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda and 4 more

Abstract readComparative Study
In one paragraph

Article in World journal of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Naoko SekiguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0001-7405-8596
Hidenori TakahashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0003-4801-3540
Hirofumi AkitaDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-3115-9466
Kazuki SasakiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.
Shinichiro HasegawaDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.
Yoshifumi IwagamiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.
Daisaku YamadaDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-6702-3800
Yoshito TomimaruDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-4432-060X
Tadafumi AsaokaDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.
Takehiro NodaDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-6768-5783
Junzo ShimizuDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-6613-5341
Shogo KobayashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-8828-1067
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, the University of Osaka, Suita City, Osaka, Japan.ORCID https://orcid.org/0000-0002-2318-1129

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between the radiographic portal vein-superior mesenteric vein (PV-SMV) involvement and pathological PV-SMV (pPV) invasion has been established in upfront surgery cases of pancreatic cancer (PC); however, evidence remains limited for patients receiving neoadjuvant therapy (NAT). This study aimed to evaluate the association of radiographic findings with pPV invasion in patients treated with NAT, and to examine whether this association differs between patients treated with neoadjuvant chemotherapy (NAC) and neoadjuvant chemoradiotherapy (NACRT).

methodsWe retrospectively analyzed patients with PC whose tumors contacted the PV-SMV on radiographic imaging before or after NAT. The relationship between radiographic findings and pPV invasion was evaluated in subgroups defined by pre- and post-NAT imaging findings.

resultsTumor size, PV-SMV contact length, and contact angle were significantly reduced in post-NAT imaging. Radiographic PV-SMV involvement showed limited association with pPV invasion in the entire cohort. The overall pPV invasion rate was 15% and did not differ between the NAC and NACRT groups (17% vs. 13%, p = 0.790). Among patients with a pre-NAT tumor size of < 20 mm, the pPV invasion rate was significantly lower in the NACRT group than in the NAC group (29% vs. 0%, p = 0.007). This difference was not observed in patients with a pre-NAT tumor size ≥ 20 mm (12% vs. 19%, p = 0.438). Across other radiographic classifications, pPV invasion rates remained comparable between treatment groups.

conclusionsThe association of radiographic findings with pPV invasion differs between patients treated with NAC and NACRT in patients with small tumors.

Indexed as

ChemoradiotherapyMesenteric VeinsNeoadjuvant TherapyPancreatic NeoplasmsPortal VeinAgedChemoradiotherapy, AdjuvantChemotherapy, AdjuvantFemaleHumansMaleMiddle AgedNeoplasm InvasivenessRetrospective StudiesTomography, X-Ray ComputedNATpancreatic cancerpathological PV‐SMV invasionprognosisradiographic PV‐SMV involvement

Identifiers

PMID42095757
PMCPMC13242061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.