Observational studyJournal of the American Geriatrics Society2026
Association of Combined Lifestyle Behaviors With Healthspan in Older Adults.
Observational study in Journal of the American Geriatrics Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01038583 (Aspirin in Reducing Events in the Elderly), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Aspirin in Reducing Events in the Elderly
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0 citing papers in PubMed.
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Authors and funding
14 authors.
Funding
Abstract
backgroundAs populations age, extending healthspan, or years lived in good health, is a global priority. Most evidence on healthy lifestyle and prolonged healthspan comes from middle-aged or comorbid populations, leaving it unclear whether benefits apply to healthy older adults. This study evaluates whether combined lifestyle behaviors are associated with disability-free survival in community-dwelling older adults.
methodsThe study included 11,287 Australian participants (median age 74 [IQR 72-77]) from the ASPirin in Reducing Events in the Elderly (ASPREE) study, with a median follow-up of 6.6 years (IQR 5.5-7.9). Participants received one point for adherence to each of the following lifestyle factors: Mediterranean diet, moderate physical activity, non-smoking, and moderate alcohol consumption and categorized as having low (0-1 factors), moderate (2 factors), or favorable (≥ 3 factors) lifestyle. The primary outcome was a composite endpoint comprised of the first occurrence of either death, dementia, or persistent physical disability. Associations of lifestyle categories with the composite endpoint and the individual components were examined, alongside effect modification by key demographic and health variables. Years gained in disability-free survival and compression of morbidity were calculated.
resultsCompared to those with an unfavorable lifestyle, a moderate [HR 0.75 (95% CI 0.65-0.87)] and favorable [HR 0.60 (95% CI 0.52-0.70)] lifestyle were associated with a lower risk of the composite endpoint. Over a median of 6.6 years, a favorable lifestyle was prospectively associated with a 10% gain in years of healthspan and a moderate compression of morbidity. Associations did not differ across groups of age, sex, education, aspirin treatment, BMI, diabetes, and hypertension.
conclusionIn healthy older adults, adherence to a healthy lifestyle was associated with a greater likelihood of surviving free from disability and dementia and was prospectively linked with a prolonged healthspan and a compression of morbidity, highlighting its potential importance in promoting healthy aging.
trial registrationClinicalTrials.gov identifier: NCT01038583.
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