Evidence map›Paper›PMID 42095655›Full record

ArticlemSphere2026

Isolation of a highly virulent colibactin-positive tumor-promoting strain of

Allison M Weis, O'Connor J Matthews, Rickesha Bell, Nicole Lynn Pershing, Annika Dankwardt, Brittany A Fleming, Biljana Gigic, Martin Schneider, Sheetal Hardikar, Adetunji T Toriola and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Allison M WeisDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.ORCID 0000-0001-9991-1661
O'Connor J MatthewsSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.
Rickesha BellDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Nicole Lynn PershingDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Annika DankwardtDepartment of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Brittany A FlemingDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Biljana GigicDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Martin SchneiderDepartment of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.
Sheetal HardikarDepartment of Population Health Science, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Adetunji T ToriolaDivision of Public Health Sciences, Department of Surgery, Siteman Cancer Center Washington University School of Medicine, St. Louis, Missouri, USA.
David ShibataDepartment of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Christopher I LiDivison of Public Health, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Doratha A ByrdDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.ORCID 0000-0003-4275-7901
W Zac StephensDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.ORCID 0000-0002-8072-9023
Cornelia M UlrichDepartment of Population Health Science, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Matthew A MulveySchool of Biological Sciences, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0002-6016-7510
June L RoundDepartment of Pathology, Division of Microbiology and Immunology, University of Utah School of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.ORCID 0000-0002-7158-9874

Funding

Determining immune-mediated mechanisms of beneficial bacteria in colon cancerK22CA289144 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ALLISON WEIS · 2025 to 2026
$404k
Determining how the human gut microbiota modulates colon cancer tumorigenesisF32CA243501 · NCI · UNIVERSITY OF UTAH · PI WEIS, ALLISON · 2019 to 2021
$200k
Common Fund F32CA243501, 1K22CA289144-01Common Fund R01AT011423Common Fund R01GM134331, R21AI135918NCI NIH HHS F32 CA243501NCI NIH HHS K22 CA289144
6 · The paper itself

Abstract

Recent studies have pointed to critical roles for microbes in both exacerbation of and protection from the development of colon cancer. While much has been learned, the field remains understudied, with functional studies available for only a handful of bacteria. To identify novel microbes associated with colorectal cancer (CRC) development, we employed a preclinical chemical carcinogenesis CRC mouse model using germ-free mice that were colonized with human microbiotas. During the course of these studies, we identified a microbiota that exacerbated CRC, from which we isolated an

Indexed as

Colorectal NeoplasmsEscherichia coliGastrointestinal MicrobiomePeptidesPolyketidesAnimalsCarcinogenesisColitisDisease Models, AnimalEscherichia coli InfectionsFemaleHumansMiceMice, Inbred C57BLSepsisVirulencecolibactinPeptidesPolyketidescolon cancerE. colihuman microbiomepathogentumor promoting microbes

Identifiers

PMID42095655
PMCPMC13203963

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.