Evidence map›Paper›PMID 42095648›Full record

ArticlePlant biotechnology journal2026

OsMYB306-OsRAV11 Regulates Resistance of Rice to Striped Stem Borer by Modulating Serotonin Biosynthesis.

Jia-Run Zhang, Long Wang, Yang-Fan Chen, Xiao-Hao Guo, Meng Jiang, Yuan-Yuan Tan, Qing Wang, Qiu Qian, Angharad M R Gatehouse, Qing-Yao Shu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-Run ZhangState Key Laboratory of Rice Biology & Breeding, and Zhejiang Provincial Key Laboratory of Crop Germplasm Innovation and Exploitation, The Advanced Seed Institute, Zhejiang University, Hangzhou, China.
Long WangState Key Laboratory of Rice Biology & Breeding, and Zhejiang Provincial Key Laboratory of Crop Germplasm Innovation and Exploitation, The Advanced Seed Institute, Zhejiang University, Hangzhou, China.
Yang-Fan ChenState Key Laboratory of Rice Biology & Breeding, and Zhejiang Provincial Key Laboratory of Crop Germplasm Innovation and Exploitation, The Advanced Seed Institute, Zhejiang University, Hangzhou, China.
Xiao-Hao GuoState Key Laboratory of Rice Biology & Breeding, and Zhejiang Provincial Key Laboratory of Crop Germplasm Innovation and Exploitation, The Advanced Seed Institute, Zhejiang University, Hangzhou, China.
Meng JiangHainan Institute, Zhejiang University, Sanya, China.ORCID https://orcid.org/0000-0002-7498-7093
Yuan-Yuan TanState Key Laboratory of Rice Biology & Breeding, and Zhejiang Provincial Key Laboratory of Crop Germplasm Innovation and Exploitation, The Advanced Seed Institute, Zhejiang University, Hangzhou, China.
Qing WangZhejiang University - Wuxi Xishan Joint Modern Agricultural Research Centre, Zhejiang University, Hangzhou, China.
Qiu QianZhejiang University - Wuxi Xishan Joint Modern Agricultural Research Centre, Zhejiang University, Hangzhou, China.
Angharad M R GatehouseSchool of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, UK.ORCID https://orcid.org/0000-0002-6406-2927
Qing-Yao ShuState Key Laboratory of Rice Biology & Breeding, and Zhejiang Provincial Key Laboratory of Crop Germplasm Innovation and Exploitation, The Advanced Seed Institute, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-9201-0593

Funding

Hainan Provincial Department of Science and Technology ZDYF2025XDNY093National Natural Science Foundation of China 32072034
6 · The paper itself

Abstract

Striped stem borer (SSB; Chilo suppressalis Walker) is one of the most destructive pests in rice production. Previous studies have demonstrated that SSB infestation induces transcription of OsT5H (tryptamine-5-hydroxylase) and biosynthesis of serotonin, a newly recognised phytohormone, and that disruption of serotonin biosynthesis significantly increases SSB resistance. However, the regulatory module modulating serotonin biosynthesis remains to be identified and characterised. Here, we reveal an OsMYB306-OsRAV11 module that regulates OsT5H transcription and serotonin biosynthesis in response to SSB infestation in rice. OsMYB306 and OsRAV11 can bind to the OsT5H promoter and repress its transcription. In the module, OsRAV11 interacts with OsMYB306 and enhances its inhibitory effect on OsT5H transcription. CRISPR/Cas9-generated knockout mutants (myb306, rav11 and myb306 rav11) exhibited elevated OsT5H expression, increased serotonin accumulation and reduced SSB resistance. Conversely, OsRAV11 overexpression reduced OsT5H transcription. Our findings establish a transcriptional regulatory framework for the biosynthesis of serotonin in response to SSB infestation. These findings inform the development of new strategies for producing SSB-resistant rice by genome editing, potentially reducing reliance on chemical pesticides for SSB control.

Indexed as

MothsOryzaPlant ProteinsSerotoninTranscription FactorsAnimalsDisease ResistanceGene Expression Regulation, PlantPromoter Regions, GeneticPlant ProteinsSerotoninTranscription FactorsOsMYB306OsRAV11riceserotoninstriped stem borertranscriptional regulationtryptamine 5‐hydroxylase

Identifiers

PMID42095648
PMCPMC13387888

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.