Evidence map›Paper›PMID 42095470›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up-Regulating GATA1/METTL1/SLC7A11 Axis.

Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wenxin HuangResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yi SunResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Yanxin WangResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Haijun YanResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Xiaoping YueInstitute of Flow Chemistry and Engineering, College of Chemistry and Materials, Jiangxi Normal University, Nanchang, Jiangxi, P. R. China.
Weidong WuSchool of Public Health, Henan Medical University, Xinxiang, Henan Province, China.
Xueyu ChenDepartment of Reproductive Medicine, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong Province, China.
Jinfang ZhangCancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.
Yanbing LinResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Qiong LeiDepartment of Obstetrics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong Province, China.
Nan JiFaculty of Health Sciences Building, University of Macau, Taipa, Macau, China.
Shuaishuai XingResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Liqin ZengCancer Center, Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, China.
Qingzheng KangResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
Depeng ZhaoDepartment of Reproductive Medicine, Women and Children's Medical Center, Shenzhen School of Clinical Medicine, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, Guangdong Province, China.
Geng GuoDepartment of Emergency, Cerebrovascular Disease Center, First Hospital of Shanxi Medical University, Taiyuan, China.
Huidong ZhangResearch Center for Environment and Female Reproductive Health, Biological Laboratory of Hetao Cooperation Zone, the Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.ORCID https://orcid.org/0000-0001-7845-3331

Funding

China Postdoctoral Science Foundation 2025M780729Futian Healthcare Research FTWS011Guangdong Basic and Applied Basic Research Foundation 2023A1515110497Guangdong Basic and Applied Basic Research Foundation 2023B1515120054Health Commission of Guangdong Province A2024281MOE Key Laboratory of Coal Environmental Pathogenicity and PreventionNational Key R&D Program of China 2025YFC2708402Natural Science Foundation of China 82373602Natural Science Foundation of China 82571347Sanming Project of Medicine in Shenzhen SZSM202411034Shanxi Province Higher Education "BillionProject" Science and Technology Guidance ProjectShenzhen Medical Research Fund B2303002Shenzhen Science and Technology Program JCYJ20230807111401002Shenzhen Science and Technology Program JCYJ20240813180400002Shenzhen Science and Technology Program JCYJ20241202152800001Shenzhen Science and Technology Program JCYJ20250604142511015Shenzhen Science and Technology Program JCYJ20250604142519025
6 · The paper itself

Abstract

The pathogenesis of unexplained miscarriage (UM) is largely unclear. Environmental Zn pollution is widely present in various environments and inevitably ingested by pregnant women, which has shown reproductive toxicity. Disulfidptosis is a newly identified programmed cell death caused by excessive disulfide stress. Notably, the association, causation, and underlying mechanisms among Zn exposure, disulfidptosis, and unexplained miscarriage are completely unknown. In this study, based on two UM case-control groups, four ZnCl

Indexed as

Abortion, SpontaneousDisulfidptosisGATA1 Transcription FactorZincAnimalsFemaleHumansMicePregnancyUp-RegulationGATA1 protein, humanGATA1 Transcription FactorZincdisulfidptosism7G RNA modificationSLC7A11unexplained miscarriageZn exposure

Identifiers

PMID42095470
PMCPMC13334944

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.