ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Pre-pregnancy obesity, gestational weight gain, and their relationship with maternal lipid levels at delivery across racial and ethnic populations.
Xinyuan X Laufer, Antonina I Frolova, Nandini Raghuraman, Samantha L Martin, Sarah K England, Molly J Stout, Valene Garr Barry
Abstract read
In one paragraphArticle in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Xinyuan X LauferDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0003-4944-9047 Antonina I FrolovaDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0002-6491-6910 Nandini RaghuramanDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, Missouri, United States.
Samantha L MartinDepartment of Obstetrics and Gynecology, Center for Research in Women's Health, University of Alabama at Birmingham, Birmingham, Alabama, United States.
Sarah K EnglandDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, Missouri, United States.ORCID 0000-0003-4247-0281 Molly J StoutDepartment of Obstetrics and Gynecology, Maternal-Fetal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, United States.
Valene Garr BarryDepartment of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, St. Louis, Missouri, United States.
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWashington University Institute of Clinical and Translational Sciences (KL2) KL2TR002346 · NCATS · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 2017 to 2026
$14.0MAn investigation of the long-term impact of in-utero exposure to mild chronic hypertension and antihypertensive therapy on childhood subclinical cardiovascular risk factorsK01HL166370 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Samantha L Martin · 2024 to 2026
$500kA Precision Medicine Approach to Fetal Growth Restriction Among Black WomenK01MD020519 · NIMHD · WASHINGTON UNIVERSITY · PI Valene Elizabeth Garr Barry · 2025 to 2026
$269kHHS | NIH | National Center for Advancing Translational Sciences (NCATS) KL2TR002346HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL166380March of Dimes Foundation (MDF)NCATS NIH HHS KL2 TR002346NHLBI NIH HHS K01 HL166370NIDDK NIH HHS P30 DK056341NIMHD NIH HHS K01 MD020519
6 · The paper itselfAbstract
Maternal dyslipidemia is associated with adverse pregnancy outcomes and long-term cardiovascular risk. Prepregnancy obesity and excessive gestational weight gain may exacerbate dysfunctional lipid profiles, particularly at full term gestation when lipid burden peaks. However, studies on maternal lipids at delivery are lacking. This study aims to examine the associations of prepregnancy BMI (pBMI) and gestational weight gain (GWG) with maternal lipids at delivery across a cohort composed of two dominant ethnicities. This was a secondary analysis of a prospective study and comprised of 500 singleton pregnancies delivering at term (≥37 wk). The association of pBMI and GWG with total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) were examined by multivariate models. Analyses adjusted for potential confounders and stratified by race. Sensitivity analyses omitted gestational diabetes and hypertensive disorders. Participants had pBMI of 28.4 ± 7.5 kg/m
Indexed as
DyslipidemiasGestational Weight GainLipidsObesityPregnancy ComplicationsAdultBiomarkersBlack or African AmericanBody Mass IndexFemaleHumansPregnancyProspective StudiesRace FactorsRisk FactorsTriglyceridesBiomarkersLipidsTriglyceridesgestational weight gainlipidsobesitypregnancyrace and ethnicity
Identifiers
PMID42095460
PMCPMC13379201
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