Evidence map›Paper›PMID 42095416›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine.

Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O Larkotey, Yang Li and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xinran LiuState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Xin ChenState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Qingyang ZhaoState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Weikang TanState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Lingrui ZhuState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Kin LiaoAdvanced Digital and Additive Manufacturing Center, Khalifa University of Science and Technology, Abu Dhabi, UAE.
Vincent ChanAdvanced Digital and Additive Manufacturing Center, Khalifa University of Science and Technology, Abu Dhabi, UAE.ORCID https://orcid.org/0009-0005-3593-2822
Nicolae GogaMolecular Dynamics Group, University of Groningen, Groningen, The Netherlands.
Winfred O LarkoteyDepartment of Computing Sciences and Engineering, Valley View University, Accra, Ghana.ORCID https://orcid.org/0000-0003-4764-3874
Yang LiEngineering Research Center of Personalized Anti-Aging Health Product Development and Transformation of Universities of Shaanxi Province and College of Medicine, Xi'an International University, Xi'an, China.
Yinghui ShiState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Wenya ShuState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
Lin WangEngineering Research Center of Personalized Anti-Aging Health Product Development and Transformation of Universities of Shaanxi Province and College of Medicine, Xi'an International University, Xi'an, China.
Weiqing WangDepartment of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Tian Jian LuState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.ORCID https://orcid.org/0000-0001-7795-7511
Yulong HanState Key Laboratory of Mechanics and Control for Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, China.

Funding

Education Department of Shaanxi Provincial Government 24JP160National Natural Science Foundation of China 12032010National Natural Science Foundation of China 12202193National Natural Science Foundation of China 12572348National Natural Science Foundation of China 32271296Open Research Fund of the Key Laboratory of Acupuncture and Medicine Combination zykf202308Technology Innovation Leading Program of Shaanxi 2024QCY-KXJ069Youth Innovation Team of Shaanxi Universities
6 · The paper itself

Abstract

The cell nucleus serves as the central hub of genetic information and a dynamic, multiscale mechanosensor that regulates critical cellular behaviors, such as gene expression and cell migration. Functioning as a complex soft matter system, the nucleus comprises a hierarchical architecture spanning from nanoscale DNA and nucleosomes to microscale chromosome territories and the nuclear envelope. This multiscale structural organization endows the nucleus with scale-dependent mechanical properties-such as stiffness and viscoelasticity-that are fundamental to cellular mechanotransduction and the strict regulation of nuclear entry for therapeutic nanoparticles. This review emphasizes the recent advances in understanding the multiscale architecture and mechanics of the cell nucleus. We compare experimental technologies for probing nuclear mechanics, alongside emerging multiscale theoretical models that transform these qualitative observations into quantitative, predictive frameworks for mechanobiology and nanomedicine. Finally, we highlight the translational implications of nuclear mechanics on nuclear-targeted nanomedicine, mechanodiagnosis, and mechanotherapy.

Indexed as

BioengineeringCell NucleusMechanotransduction, CellularNanomedicineAnimalsBiomechanical PhenomenaHumans

Identifiers

PMID42095416
PMCPMC13334631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.