Evidence map›Paper›PMID 42095415›Full record

ArticleJournal of natural products2026

Parallel Pathways and Alternative Macrocyclizations in the Biosynthesis of Largimycins by Cytochrome P450 Minus Mutants of

Adriana Becerril, Ignacio Pérez-Victoria, Jesús Martín, José A Salas, Fernando Reyes, Carmen Méndez

Abstract read
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adriana BecerrilDepartamento de Biología Funcional, Universidad de Oviedo, Oviedo 33006, Spain.
Ignacio Pérez-VictoriaDepartment of Biotechnology and Environmental Protection, Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada 18008, Spain.ORCID 0000-0002-4556-688X
Jesús MartínFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada 18016, Spain.ORCID 0000-0001-7487-2790
José A SalasDepartamento de Biología Funcional, Universidad de Oviedo, Oviedo 33006, Spain.
Fernando ReyesFundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, Granada 18016, Spain.ORCID 0000-0003-1607-5106
Carmen MéndezDepartamento de Biología Funcional, Universidad de Oviedo, Oviedo 33006, Spain.ORCID 0000-0003-2729-841X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Largimycins are a recently discovered group of hybrid nonribosomal peptide-polyketide compounds belonging to the leinamycin family of natural products. They are produced in

Indexed as

Cytochrome P-450 Enzyme SystemStreptomycesCyclizationLactamsMacrolidesMolecular StructureMultigene FamilyMutationThiazolesThionesCytochrome P-450 Enzyme SystemLactamsleinamycinMacrolidesThiazolesThiones

Identifiers

PMID42095415
PMCPMC13200230

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.