ArticleAngewandte Chemie (International ed. in English)2026
Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal-Chelate-Modified Deoxyribonucleoside Triphosphates.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report the first enzymatic synthesis of precisely defined metal-oligonucleotide conjugates through template-directed polymerase-mediated primer extension with two different (radio)metal-chelator-modified deoxyribonucleoside triphosphates. We successfully incorporated five different metals (Ga, In, Tb, Lu, and Y) along designed oligonucleotide templates, including the simultaneous incorporation of two different metal chelates within a given strand. To provide bio-orthogonality, this approach exploits the well-known enzymatic fidelity of DNA polymerase to generate uniformly metal-loaded DNA constructs with well-defined and programmable compositions. The platform is validated using chelators DOTA and DTPA and confirmed by both inductively coupled plasma mass spectrometry (ICP-MS) quantification and autoradiographic analysis following gel electrophoresis to demonstrate radioisotope incorporation with clinically relevant metals (
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