ArticleFrontiers in nutrition2026
Baseline triglyceride-cholesterol-body weight index and risk of incident cardiovascular disease: evidence from the CHARLS and ELSA cohorts.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The triglyceride-cholesterol-body weight index (TCBI) has been proposed as a composite indicator of nutritional-metabolic status, yet evidence regarding its association with incident CVD in general aging populations and across different modeling strategies remains limited. Methods: We analyzed harmonized data from the China Health and Retirement Longitudinal Study (CHARLS: 2011-2018) and the English Longitudinal Study of Aging (ELSA: 2002-2018). Community-dwelling adults aged 45 years and older and free of CVD at baseline were included. Baseline TCBI was calculated as triglycerides × total cholesterol × body weight /1,000 and primarily analyzed as a log-transformed continuous variable. Incident CVD was defined as physician-diagnosed heart disease or stroke during follow-up. Cox proportional hazards models, restricted cubic spline analyses, and prespecified subgroup analyses were conducted separately in each cohort. Results: A total of 6,013 participants (CHARLS: 3,741; ELSA: 2,272) were included. In the fully adjusted model, higher baseline TCBI was significantly associated with incident CVD in both cohorts (CHARLS: HR = 1.216, 95% CI (1.092, 1.352); Conclusions: Higher baseline TCBI was associated with incident CVD in two large aging cohorts, especially when modeled as a continuous exposure. However, its incremental predictive value beyond conventional cardiovascular risk factors was minimal. TCBI may therefore serve as a complementary metabolic and nutritional indicator rather than a stand-alone predictive tool.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.